HOTAIR：一种潜在的转移性、耐药性和乳腺癌预后调节因子。
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer.
机构信息
Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea.
NanoBio High-Tech Materials Research Center, Biological Sciences and Bioengineering, Inha University, Incheon, 22212, Republic of Korea.
出版信息
Mol Cancer. 2023 Mar 30;22(1):65. doi: 10.1186/s12943-023-01765-3.
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.
HOX 转录反义基因间 RNA（HOTAIR）是一种致癌性非编码 RNA，其表达与多种癌症（包括乳腺癌）的肿瘤分级和预后密切相关。HOTAIR 通过海绵和表观遗传机制调节各种靶基因，并控制包括转移和耐药性在内的各种致癌细胞和信号机制。在乳腺癌细胞中，HOTAIR 的表达受到多种转录和表观遗传机制的调节。在这篇综述中，我们描述了在癌症发展过程中调控 HOTAIR 表达的调节机制，并探讨了 HOTAIR 如何驱动乳腺癌的发展、转移和耐药性。在这篇综述的最后一节，我们重点关注 HOTAIR 在乳腺癌管理、治疗和预后中的作用，强调其潜在的治疗应用。
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