Clinical Pharmacology Department, Virgen del Rocío University Hospital, Seville, Spain.
Cardiology Department, Virgen del Rocío University Hospital, Seville, Spain.
Curr Drug Saf. 2024;19(1):154-158. doi: 10.2174/1574886318666230329123459.
Reported cases after the post-commercialization phase of mRNA vaccines against COVID-19 have revealed that myocarditis and pericarditis may occur predominantly in male adolescents after the second dose of the vaccine.
We report two cases of cardiac disorders associated with mRNA COVID-19 vaccination, both of them in 15 year-old males. One of the patients presented acute pericarditis and the second one presented acute myocarditis with left ventricular dysfunction at hospital discharge.
Physicians should be aware with the typical manifestations of these cardiovascular events after the vaccination and report suspicious cases to pharmacovigilance agencies as soon as possible. The population should rely on the pharmacovigilance system that continues to recommend vaccination as the most effective strategy to reduce the negative consequences of the pandemic.
在 COVID-19 的 mRNA 疫苗商业化阶段之后报告的病例显示,心肌炎和心包炎可能主要发生在第二剂疫苗接种后的男性青少年中。
我们报告了两例与 mRNA COVID-19 疫苗接种相关的心脏疾病,均发生在 15 岁男性中。其中一名患者表现为急性心包炎,另一名患者表现为急性心肌炎,出院时左心室功能障碍。
医生应该意识到接种疫苗后这些心血管事件的典型表现,并尽快向药物警戒机构报告可疑病例。人群应依靠药物警戒系统,继续推荐接种疫苗,这是减轻大流行负面影响的最有效策略。