多发性硬化症：神经免疫相互作用和治疗靶点。
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting.
机构信息
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
出版信息
Cell. 2023 Mar 30;186(7):1309-1327. doi: 10.1016/j.cell.2023.03.008.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system afflicting nearly three million individuals worldwide. Neuroimmune interactions between glial, neural, and immune cells play important roles in MS pathology and offer potential targets for therapeutic intervention. Here, we review underlying risk factors, mechanisms of MS pathogenesis, available disease modifying therapies, and examine the value of emerging technologies, which may address unmet clinical needs and identify novel therapeutic targets.
摘要
多发性硬化症（MS）是一种慢性炎症性和退行性疾病，影响全球近 300 万人。神经胶质细胞、神经元和免疫细胞之间的神经免疫相互作用在 MS 病理学中发挥着重要作用，并为治疗干预提供了潜在的靶点。在这里，我们回顾了潜在的风险因素、MS 发病机制的机制、现有的疾病修饰疗法，并探讨了新兴技术的价值，这些技术可能满足未满足的临床需求并确定新的治疗靶点。
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