Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210002, P. R. China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Adv Mater. 2023 Jul;35(28):e2301192. doi: 10.1002/adma.202301192. Epub 2023 May 24.
Microparticles (MPs)-based delivery systems have a demonstrated value in gastrointestinal administration. Research in this area is focusing on the development of multifunctional MPs to improve delivery effects. Herein, learning from the natural morphology of peony pollens, novel multilobe MPs delivery systems for target surface adhesion and durable drug release are pesented. Ascribing to the flexibility of microfluidic technology and the combination of selective hydrogel degradation methods, MPs with a series of multilobe structures can be obtained using alginate and methacrylated gelatin. Compared with spherical MPs, these multilobe MPs are elucidated to show excellent adhesion capacity due to their enhanced contact area. By encapsulating anti-inflammatory agent dexamethasone (DXM) into their matrix hydrogel, the resultant multilobe MPs delivery systems are verified to feature durable drug-release property and anti-inflammatory efficacy, which is further demonstrated in rats with inflammatory bowel disease. These results indicated that the biomimetic multilobe MPs are potentially ideal adhesive and durable drug-delivery vehicles for gastrointestinal drug administrations.
基于微粒（MPs）的递药系统在胃肠道给药方面具有明显的价值。该领域的研究集中于开发多功能 MPs 以改善递药效果。在此，受牡丹花粉天然形态的启发，提出了用于靶向表面黏附及持久药物释放的新型多叶 MPs 递药系统。借助微流控技术的灵活性和选择性水凝胶降解方法的结合，使用海藻酸钠和甲基丙烯酰化明胶可以获得具有一系列多叶结构的 MPs。与球形 MPs 相比，由于接触面积增加，这些多叶 MPs 表现出优异的黏附能力。通过将抗炎剂地塞米松（DXM）包封到基质水凝胶中，证实所得的多叶 MPs 递药系统具有持久的药物释放性能和抗炎功效，在炎症性肠病大鼠中得到了进一步验证。这些结果表明，仿生多叶 MPs 可能是胃肠道给药的理想黏附性和持久性药物递送载体。
