食管癌在线自适应放疗中的分次内运动分析
Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer.
作者信息
Boekhoff Mick R, Lagendijk Jan J W, van Lier Astrid L H M W, Mook Stella, Meijer Gert J
机构信息
Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
出版信息
Phys Imaging Radiat Oncol. 2023 Mar 20;26:100432. doi: 10.1016/j.phro.2023.100432. eCollection 2023 Apr.
Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.
对磁共振（MR）引导下食管癌肿瘤剂量输送过程中的分次内运动进行了回顾性分析。电影磁共振系列的可变形图像配准产生了肿瘤总体积在各个方向上的运动轮廓，随后对其进行滤波以分离呼吸运动和漂移运动。观察到患者之间分次内运动模式存在很大差异。在头足、左右和前后方向上，95%峰峰值运动的中位数分别为7.7（3.7 - 18.3）mm、2.1（0.7 - 5.7）mm和2.4（0.5 - 5.6）mm。此外，分次内漂移通常较小（<5mm）。对于大多数患者，采用患者特异性方法可能会导致非常小的边界（<3mm）。
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