基于明胶的抗癌药物递送纳米系统：一篇综述
Gelatin-based anticancer drug delivery nanosystems: A mini review.
作者信息
Jiang Xianchao, Du Zhen, Zhang Xinran, Zaman Fakhar, Song Zihao, Guan Yuepeng, Yu Tengfei, Huang Yaqin
机构信息
Beijing Laboratory of Biomedical Materials, Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing, China.
Beijing Key Laboratory of Clothing Materials R&D and Assessment, Beijing Engineering Research Center of Textile Nano Fiber, Beijing Institute of Fashion Technology, Beijing, China.
出版信息
Front Bioeng Biotechnol. 2023 Mar 21;11:1158749. doi: 10.3389/fbioe.2023.1158749. eCollection 2023.
Drug delivery nanosystems (DDnS) is widely developed recently. Gelatin is a high-potential biomaterial originated from natural resources for anticancer DDnS, which can effectively improve the utilization of anticancer drugs and reduce side effects. The hydrophilic, amphoteric behavior and sol-gel transition of gelatin can be used to fulfill various requirements of anticancer DDnS. Additionally, the high number of multifunctional groups on the surface of gelatin provides the possibility of crosslinking and further modifications. In this review, we focus on the properties of gelatin and briefly elaborate the correlation between the properties and anticancer DDnS. Furthermore, we discuss the applications of gelatin-based DDnS in various cancer treatments. Overall, we have summarized the excellent properties of gelatin and correlated with DDnS to provide a manual for the design of gelatin-based materials for DDnS.
药物递送纳米系统（DDnS）近年来得到了广泛发展。明胶是一种具有高潜力的生物材料，源自天然资源，用于抗癌药物递送纳米系统，它可以有效提高抗癌药物的利用率并减少副作用。明胶的亲水性、两性行为和溶胶-凝胶转变可用于满足抗癌药物递送纳米系统的各种要求。此外，明胶表面大量的多功能基团提供了交联和进一步修饰的可能性。在这篇综述中，我们重点关注明胶的特性，并简要阐述这些特性与抗癌药物递送纳米系统之间的相关性。此外，我们还讨论了基于明胶的药物递送纳米系统在各种癌症治疗中的应用。总体而言，我们总结了明胶的优异特性，并将其与药物递送纳米系统相关联，以为基于明胶的药物递送纳米系统材料设计提供指南。
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