基于 Au 纳米酶的 Tollens 反应级联催化：葡萄糖氧化酶样机制的研究。
Au Nanozyme Driven Cascading Catalysis in Tollens' Reaction: An Insight of Glucose Oxidase-Like Mechanism.
机构信息
Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, P. R. China.
Department of Very Important People Unit, China-Japan Union Hospital of Jilin University, Changchun, 130033, P. R. China.
出版信息
Chemistry. 2023 Jun 19;29(34):e202300454. doi: 10.1002/chem.202300454. Epub 2023 May 2.
Au nanoparticles (NPs) have been proven to be excellent glucose oxidase (GOx) mimics, which can catalyze the electrons transform pathway from glucose to oxygen. This study confirmed AuNPs can accelerate the reaction between [Ag(NH ) ] and glucose under alkaline conditions, which is also known as the Tollens' reaction, and the possible mechanism was proposed. Here, [Ag(NH ) ] instead of O acted directedly as an electron acceptor during glucose oxidation catalyzed by AuNPs, accompanied by hydrogen transfer. The as-synthesized Ag nanoparticles can also catalyze this process, similar to AuNPs, via a unique cascading catalysis mechanism in the Tollens' reaction. A simple and heatless glucose colorimetric assay can be established based on the plasmonic band of AgNPs with a liner range of 0.6-22.2 μM, and the limit of detection is 0.32 μM.
金纳米粒子（AuNPs）已被证明是极好的葡萄糖氧化酶（GOx）模拟物，可催化葡萄糖向氧气的电子转化途径。本研究证实 AuNPs 可在碱性条件下加速[Ag(NH3)2]+与葡萄糖之间的反应，即 Tollens 反应，并提出了可能的机制。在此，[Ag(NH3)2]+直接替代 O 作为 AuNPs 催化葡萄糖氧化过程中的电子受体，伴随氢转移。所合成的 Ag 纳米粒子也可以通过 Tollens 反应中的独特级联催化机制，类似于 AuNPs 一样催化这一过程。基于 AgNPs 的等离子体带，可建立一种简单且无需加热的葡萄糖比色测定法，线性范围为 0.6-22.2 μM，检测限为 0.32 μM。
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