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活体肝移植技术、匹配和手术培训的进展和创新:活体肝移植共识会议的报告。

Advances and innovations in living donor liver transplant techniques, matching and surgical training: Meeting report from the living donor liver transplant consensus conference.

机构信息

University of Washington Medical Center, Seattle, Washington, USA.

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

出版信息

Clin Transplant. 2023 Jul;37(7):e14968. doi: 10.1111/ctr.14968. Epub 2023 Apr 11.

Abstract

The practice of LDLT currently delivers limited impact in western transplant centers. The American Society of Transplantation organized a virtual consensus conference in October 2021 to identify barriers and gaps to LDLT growth, and to provide evidence-based recommendations to foster safe expansion of LDLT in the United States. This article reports the findings and recommendations regarding innovations and advances in approaches to donor-recipient matching challenges, the technical aspects of the donor and recipient operations, and surgical training. Among these themes, the barriers deemed most influential/detrimental to LDLT expansion in the United States included: (1) prohibitive issues related to donor age, graft size, insufficient donor remnant, and ABO incompatibility; (2) lack of acknowledgment and awareness of the excellent outcomes and benefits of LDLT; (3) ambiguous messaging regarding LDLT to patients and hospital leadership; and (4) a limited number of proficient LDLT surgeons across the United States. Donor-recipient mismatching may be circumvented by way of liver paired exchange. The creation of a national registry to generate granular data on donor-recipient matching will guide the practice of liver paired exchange. The surgical challenges to LDLT are addressed herein and focuses on the development of robust training pathways resulting in proficiency in donor and recipient surgery. Utilizing strong mentorship/collaboration programs with novel training practices under the auspices of established training and certification bodies will add to the breadth and depth of training.

摘要

目前,LDLT 在西方移植中心的实践影响有限。美国移植学会于 2021 年 10 月组织了一次虚拟共识会议,旨在确定 LDLT 发展的障碍和差距,并提供循证建议,以促进 LDLT 在美国的安全扩展。本文报告了有关供体-受者匹配挑战的方法创新和进展、供体和受者操作的技术方面以及外科培训的发现和建议。在这些主题中,被认为对 LDLT 在美国扩展最具影响力/不利的障碍包括:(1)与供体年龄、移植物大小、供体残肝不足和 ABO 不相容性相关的禁忌问题;(2)对 LDLT 的出色结果和益处缺乏认识和认识;(3)向患者和医院领导层传达 LDLT 的信息不明确;(4)美国熟练的 LDLT 外科医生人数有限。通过肝配对交换可以规避供体-受者不匹配的问题。创建一个全国性的登记处,生成关于供体-受者匹配的详细数据,将指导肝配对交换的实践。本文解决了 LDLT 的手术挑战,并侧重于开发强大的培训途径,从而使供体和受者手术达到熟练水平。利用强有力的指导/合作计划,结合新颖的培训实践,在既定的培训和认证机构的支持下,将增加培训的广度和深度。

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