Division of Experimental Allergy and Immunodermatology, Faculty of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.
Department of Experimental Pain Research, MCTN, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Int J Mol Sci. 2023 Mar 24;24(7):6105. doi: 10.3390/ijms24076105.
Allergic diseases are accompanied by a variety of symptoms such as pruritus, coughing, sneezing, and watery eyes, which can result in severe physiological and even psychological impairments. The exact mechanisms of these conditions are not yet completely understood. However, recent studies demonstrated a high relevance of neurotrophins in allergic inflammation, as they induce cytokine release, mediate interaction between immune cells and neurons, and exhibit different expression levels in health and disease. In this review, we aim to give an overview of the current state of knowledge concerning the role of neurotrophins in atopic disorders such as atopic dermatitis, allergic asthma, and allergic rhinitis.
过敏疾病伴有多种症状，如瘙痒、咳嗽、打喷嚏和流泪，可能导致严重的生理甚至心理障碍。这些疾病的确切机制尚不完全清楚。然而，最近的研究表明神经营养因子在过敏炎症中具有高度相关性，因为它们诱导细胞因子释放、介导免疫细胞和神经元之间的相互作用，并且在健康和疾病中表现出不同的表达水平。在这篇综述中，我们旨在概述神经营养因子在特应性皮炎、过敏性哮喘和过敏性鼻炎等特应性疾病中的作用的现有知识状态。
Zotero 插件