Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
Cell. 2023 Apr 13;186(8):1610-1626. doi: 10.1016/j.cell.2023.03.010.
Intercellular communication is a key feature of cancer progression and metastasis. Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent studies have identified EVs as key mediators of cell-cell communication via packaging and transfer of bioactive constituents to impact the biology and function of cancer cells and cells of the tumor microenvironment. Here, we review recent advances in understanding the functional contribution of EVs to cancer progression and metastasis, as cancer biomarkers, and the development of cancer therapeutics.
细胞间通讯是癌症进展和转移的关键特征。细胞外囊泡(EVs)由所有细胞产生,包括癌细胞,最近的研究已经确定 EVs 是通过包装和转移生物活性成分来影响癌细胞和肿瘤微环境细胞的生物学和功能的细胞间通讯的关键介质。在这里,我们综述了近年来对 EVs 对癌症进展和转移的功能贡献、作为癌症生物标志物以及癌症治疗开发的理解进展。