硼代苯丙氨酸的硼摄取及硼中子俘获疗法对宫颈癌细胞的影响。
Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells.
作者信息
Terada Shinichi, Tsunetoh Satoshi, Tanaka Yoshimichi, Tanaka Tomohito, Kashiwagi Hideki, Takata Takushi, Kawabata Shinji, Suzuki Minoru, Ohmichi Masahide
机构信息
Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
Department of Obstetrics and Gynecology, Osaka Medical and Pharmaceutical University, Takatsuki, Japan.
出版信息
Appl Radiat Isot. 2023 Jul;197:110792. doi: 10.1016/j.apradiso.2023.110792. Epub 2023 Apr 3.
There are few studies about boron neutron capture therapy (BNCT) for cervical cancer. The present study evaluated the biodistribution of boronophenylalanine (BPA) and the effect of BNCT on cervical cancer cell lines. BPA exposure and neutron irradiation of cervical cancer cell lines resulted in decreased survival fraction compared to irradiation only. In vivo cervical cancer tumor boron concentration was highest at 2.5 h after BPA intraperitoneal administration, and higher than in the other organs. BNCT may be effective against cervical carcinoma.
关于硼中子俘获疗法（BNCT）治疗宫颈癌的研究较少。本研究评估了硼苯丙氨酸（BPA）的生物分布以及BNCT对宫颈癌细胞系的作用。与仅进行辐照相比，对宫颈癌细胞系进行BPA暴露和中子辐照导致存活分数降低。在体内，腹腔注射BPA后2.5小时宫颈癌肿瘤中的硼浓度最高，且高于其他器官。BNCT可能对宫颈癌有效。
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