帕金森病流涎的患病率及相关因素：一项纵向前瞻性队列研究结果并与对照组比较

Prevalence and Factors Associated with Drooling in Parkinson's Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group.

作者信息

Santos-García Diego, de Deus Fonticoba Teresa, Cores Bartolomé Carlos, Feal Painceiras Maria J, Íñiguez-Alvarado Maria Cristina, Jesús Silvia, Buongiorno Maria Teresa, Planellas Lluís, Cosgaya Marina, García Caldentey Juan, Caballol Nuria, Legarda Ines, Hernández Vara Jorge, Cabo Iria, López Manzanares Lydia, González Aramburu Isabel, Ávila Rivera Maria A, Gómez Mayordomo Víctor, Nogueira Víctor, Puente Víctor, Dotor García-Soto Julio, Borrué Carmen, Solano Vila Berta, Álvarez Sauco María, Vela Lydia, Escalante Sonia, Cubo Esther, Carrillo Padilla Francisco, Martínez Castrillo Juan C, Sánchez Alonso Pilar, Alonso Losada Maria G, López Ariztegui Nuria, Gastón Itziar, Kulisevsky Jaime, Blázquez Estrada Marta, Seijo Manuel, Rúiz Martínez Javier, Valero Caridad, Kurtis Mónica, de Fábregues Oriol, González Ardura Jessica, Alonso Redondo Ruben, Ordás Carlos, López Díaz Luis M L, McAfee Darrian, Martinez-Martin Pablo, Mir Pablo, Coppadis Study Group

机构信息

CHUAC,Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain.

CHUF,Complejo Hospitalario Universitario de Ferrol, A Coruña, Spain.

出版信息

Parkinsons Dis. 2023 Apr 6;2023:3104425. doi: 10.1155/2023/3104425. eCollection 2023.

DOI:10.1155/2023/3104425

PMID:37065970

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10101739/

Abstract

INTRODUCTION

Drooling in Parkinson's disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. . PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls.

RESULTS

The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; = 0.012), being male (OR = 2.333; < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; = 0.007) as a predictor of drooling at V2.

CONCLUSION

Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.

摘要

引言

帕金森病（PD）患者流口水的情况很常见，但往往未得到充分认识。我们的目的是研究PD队列中流口水的患病率，并与对照组进行比较。具体而言，我们确定了与流口水相关的因素，并在极早期PD患者亚组中进行了亚分析。本纵向前瞻性研究纳入了2016年1月至2017年11月从西班牙35个中心的COPPADIS队列招募的PD患者（基线访视；V0），并在2年±30天的随访（V2）时再次进行评估。根据NMSS（非运动症状量表）第19项，在V0、V1（1年±15天）和V2对患者进行分类，分为有或无流口水，对对照组在V0和V2进行分类。

结果

PD患者在V0时流口水频率为40.1%（277/691）（对照组为2.4%（5/201）；<0.0001），V1时为43.7%（264/604），V2时为48.2%（242/502）（对照组为3.2%（4/124）；<0.0001），期间患病率为63.6%（306/481）。年龄较大（OR = 1.032；= 0.012）、男性（OR = 2.333；<0.0001）、基线时非运动症状（NMS）负担较重（V0时NMSS总分；OR = 1.020；<0.0001）以及从V0到V2的NMS负担增加较大（V0到V2时NMSS总分的变化；OR = 1.012；<0.0001）被确定为2年随访后流口水的独立预测因素。在症状出现≤2年的患者组中观察到类似结果，累积患病率为64.6%，V0时UPDRS-III评分较高（OR = 1.121；= 0.007）作为V2时流口水的预测因素。