Suppr超能文献

厄玛·温伯格1928年的论文《论遗传预后的判定问题:精神分裂症患者表亲的风险》

Irma Weinberg's 1928 paper "on the problem of the determination of heredity prognosis: The risk in the cousins of schizophrenics".

作者信息

Kendler Kenneth S, Klee Astrid, Engstrom Eric J

机构信息

Department of Psychiatry, The Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia, USA.

Department of Germanic Languages and Literatures, University of Toronto, Toronto, Canada.

出版信息

Am J Med Genet B Neuropsychiatr Genet. 2023 Oct-Dec;192(7-8):105-112. doi: 10.1002/ajmg.b.32937. Epub 2023 Apr 17.

Abstract

Irma Weinberg, a German-Jewish Neuropsychiatrist/Physician, authored the fourth report from the German Research Institute for Psychiatry in Munich examining the risk for dementia praecox (DP) in particular relatives of DP probands, here first-cousins. She examined 977 cousins of 54 DP probands and found a best-estimate risk of 1.4%. She conducted within-study analyses, showing a much higher risk for DP in the siblings than cousins of DP probands. She studied DP-related personalities showing a familial link between these conditions and risk for DP. She demonstrated that the risk for DP in cousins was impacted substantially by the distribution, in ancestors, of psychosis and personality abnormalities. After completing work on this article, Weinberg worked in private practice in Frankfurt, emigrating to the Netherlands in 1934, where she worked at a Jewish psychiatric hospital. In 1943, German occupiers evacuated the hospital, transporting the patients and staff, either directly to Auschwitz or, like Weinberg, to the Westerbork transit camp. On September 4, 1944, Dr. Weinberg was transported to Theresienstadt and soon thereafter to Auschwitz, where she was murdered at the age of 53. Her history raises painful questions about the relationship between genetic studies of psychiatric illness in prewar Germany and the Holocaust.

摘要

伊尔玛·温伯格是一位德裔犹太神经精神科医生,她撰写了德国慕尼黑精神病学研究所的第四份报告,该报告研究了早发性痴呆(DP)先证者的特定亲属,这里指的是一级表亲患DP的风险。她检查了54名DP先证者的977名表亲,发现最佳估计风险为1.4%。她进行了研究内分析,结果显示DP先证者的兄弟姐妹患DP的风险比其表亲高得多。她研究了与DP相关的人格,发现这些情况与DP风险之间存在家族联系。她证明,表亲患DP的风险在很大程度上受到祖先中精神病和人格异常分布的影响。完成这篇文章的工作后,温伯格在法兰克福从事私人执业,1934年移民到荷兰,在那里她在一家犹太精神病医院工作。1943年,德国占领者撤离了该医院,将患者和工作人员要么直接运往奥斯威辛,要么像温伯格一样运往韦斯特博克中转营。1944年9月4日,温伯格博士被运往特莱西恩施塔特,此后不久又被运往奥斯威辛,在那里她53岁时被谋杀。她的经历引发了关于战前德国精神疾病基因研究与大屠杀之间关系的痛苦问题。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验