非垂体 GH 对组织微环境的调节。
Non-pituitary GH regulation of the tissue microenvironment.
机构信息
Pituitary Center, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
出版信息
Endocr Relat Cancer. 2023 Jun 1;30(7). doi: 10.1530/ERC-23-0028. Print 2023 Jul 1.
Non-pituitary growth hormone (npGH) expression is well established in extrapituitary tissues, but an understanding of the physiological role of npGH remains rather limited. Pro-tumorigenic npGH impacting the tumor microenvironment has been reviewed. We focus here on autocrine/paracrine npGH effects in non-tumorous tissues and discuss its mechanisms of action in the normal tissue microenvironment. We address the tissue-specific effects of npGH in regulating stem, endothelial, immune, and epithelial cells and highlight the related role of npGH-associated changes in tissue aging.
非垂体生长激素（npGH）在垂体外组织中的表达已得到充分证实，但对 npGH 的生理作用仍知之甚少。已经有研究综述了促肿瘤 npGH 对肿瘤微环境的影响。在这里，我们重点关注非肿瘤组织中的自分泌/旁分泌 npGH 作用，并讨论其在正常组织微环境中的作用机制。我们探讨了 npGH 调节干细胞、内皮细胞、免疫细胞和上皮细胞的组织特异性作用，并强调了 npGH 相关的组织老化变化的相关作用。
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