长脉冲和调Q开关1064nm Nd:YAG激光治疗痤疮后瘢痕
Treatment of Post-acne Scarring with Long-pulsed and Q-switched 1,064nm Nd:YAG Laser.
作者信息
Gharib Khaled, Seoudy Wael, Rageh Mahmoud A, Abdelsatar Sahar, Khater Elsayed
机构信息
Drs. Gharib and Khater and Ms. Abdelsatar are with the Department of Dermatology, Faculty of Medicine, Zagazig University in Zagazig, Egypt.
Dr. Seoudy is with the Department of Dermatology, Faculty of Medicine, Misr University for Science & Technology in 6th of October City, Egypt.
出版信息
J Clin Aesthet Dermatol. 2023 Apr;16(4):32-37.
BACKGROUND
Acne scarring is one of the most dramatic consequences of inflammatory acne. It can lead to physical disfigurement and psychological burden on the affected individuals. Many treatment options for post-acne scarring are used, with variable results. Nonablative lasers, such as the 1,064nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, are known to ameliorate acne scar appearance by stimulating collagen production and dermal remodeling.
OBJECTIVES
We sought to evaluate the clinical efficacy, safety, and long-term effects of long-pulsed and Q-switched 1,064nm Nd:YAG lasers in the treatment of acne scars.
METHODS
From March to December 2019, a total of 25 patients with different skin types with acne scars were treated. Patients were divided into two groups. In Group I, 12 patients received a combination of Q-switched 1,064nm Nd:YAG laser, then long-pulsed 1,064nm Nd:YAG laser. In Group II, 13 patients received a combination of long-pulsed 1,064nm Nd:YAG laser, then Q-switched 1,064nm Nd:YAG laser. All patients received a total of six sessions at two-week intervals.
RESULTS
There were no statistically significant differences between the studied groups in skin type, lesions, or scar type. A positive response with either good or excellent results was documented in 43 patients, corresponding to 86. Six percent of the patients included in this study. Excellent response was observed in a total of 17 patients (26.6%). Twenty-six patients (60%) showed a moderate-to-good response, while seven patients (13.4 %) showed a fair response. The majority of patients in this study had an excellent-to-good response, with an 86.6% improvement of post-acne scars after laser sessions.
CONCLUSION
Q-switched and long-pulsed 1,064nm Nd:YAG lasers are considered an efficient and safe modality for the treatment of mild and moderate post-acne scars. Both lasers can enhance dermal collagen remodeling and spare the epidermis with minimal downtime after the procedure.
背景
痤疮瘢痕是炎症性痤疮最显著的后果之一。它会导致身体容貌受损，并给受影响的个体带来心理负担。针对痤疮后瘢痕有多种治疗方法，但效果各异。非剥脱性激光，如1064纳米掺钕钇铝石榴石（Nd:YAG）激光，已知可通过刺激胶原蛋白生成和真皮重塑来改善痤疮瘢痕外观。
目的
我们旨在评估长脉冲和调Q 1064纳米Nd:YAG激光治疗痤疮瘢痕的临床疗效、安全性及长期效果。
方法
2019年3月至12月，共治疗了25例不同皮肤类型的痤疮瘢痕患者。患者分为两组。第一组12例患者先接受调Q 1064纳米Nd:YAG激光治疗，然后接受长脉冲1064纳米Nd:YAG激光治疗。第二组13例患者先接受长脉冲1064纳米Nd:YAG激光治疗，然后接受调Q 1064纳米Nd:YAG激光治疗。所有患者均每隔两周共接受6次治疗。
结果
研究组在皮肤类型、皮损或瘢痕类型方面无统计学显著差异。43例患者记录有良好或极佳效果的阳性反应，占本研究纳入患者的86.6%。共17例患者（26.6%）观察到极佳反应。26例患者（60%）表现为中度至良好反应，而7例患者（13.4%）表现为一般反应。本研究中的大多数患者有极佳至良好反应，激光治疗后痤疮后瘢痕改善率达86.6%。
结论
调Q和长脉冲1064纳米Nd:YAG激光被认为是治疗轻中度痤疮后瘢痕的一种有效且安全的方式。两种激光均可增强真皮胶原蛋白重塑，且术后表皮损伤最小，恢复时间最短。
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