剖析YY1在肿瘤微环境中的作用及临床潜力。
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment.
作者信息
Li MengNa, Wei JianXia, Xue ChangNing, Zhou XiangTing, Chen ShiPeng, Zheng LeMei, Duan YuMei, Deng HongYu, Xiong Wei, Tang FaQing, Li GuiYuan, Zhou Ming
机构信息
Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Cancer Research Institute, Central South University, Changsha, China.
出版信息
Front Oncol. 2023 Apr 4;13:1122110. doi: 10.3389/fonc.2023.1122110. eCollection 2023.
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression. The tumor microenvironment (TME) is identified as the "soil" of tumor that has a critical role in both tumor growth and metastasis. Many studies have found that YY1 is closely related to the remodeling and regulation of the TME. Herein, we reviewed the expression pattern of YY1 in tumors and summarized the function and mechanism of YY1 in regulating tumor angiogenesis, immune and metabolism. In addition, we discussed the potential value of YY1 in tumor diagnosis and treatment and provided a novel molecular strategy for the clinical diagnosis and treatment of tumors.
阴阳1（YY1）是锌指蛋白GLI-Kruppel家族的成员，在肿瘤发生和肿瘤进展过程中，作为一种癌基因或肿瘤抑制因子，在癌症中发挥着至关重要的双重生物学作用。肿瘤微环境（TME）被认为是肿瘤的“土壤”，在肿瘤生长和转移中都起着关键作用。许多研究发现，YY1与TME的重塑和调节密切相关。在此，我们综述了YY1在肿瘤中的表达模式，并总结了YY1在调节肿瘤血管生成、免疫和代谢方面的功能及机制。此外，我们还讨论了YY1在肿瘤诊断和治疗中的潜在价值，并为肿瘤的临床诊断和治疗提供了一种新的分子策略。
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