Friedman Nathan, Seltzer Justin, Harvey Helen, Ly Binh, Schneir Aaron
Division of Medical Toxicology, Department of Emergency Medicine, University of California, San Diego, CA, United States.
Department of Critical Care, Rady Children's Hospital, San Diego, CA, United States.
Toxicol Rep. 2023 Apr 1;10:428-430. doi: 10.1016/j.toxrep.2023.03.006. eCollection 2023.
Ethanol remains one of the most frequently abused agents by adolescents, exceeding all others except for vaping nicotine, and use is rising. With increased ethanol use comes a greater risk for dependence and potential for alcohol withdrawal syndromes (AWS). Pediatric AWS is extremely rare and poorly characterized in the literature. Pediatric acute care practitioners may have limited exposure to AWS. We report the case of a 16-year-old male with a history of polysubstance abuse who presented with mild AWS and progressed rapidly to delirium tremens. His withdrawal was initially refractory to high dose benzodiazepine therapy but responded well to phenobarbital. This case highlights how rapidly and dangerously AWS can progress if not aggressively treated. Given the rise in adolescent alcohol use and potential for life threatening symptoms, practitioners, especially in acute care specialties such as emergency medicine, critical care, and hospital medicine, would benefit from additional familiarity with AWS diagnoses and management strategies.
乙醇仍然是青少年最常滥用的药物之一,除了吸食尼古丁外,超过了所有其他药物,而且其使用量正在上升。随着乙醇使用量的增加,依赖风险和酒精戒断综合征(AWS)的可能性也会增加。儿科AWS极为罕见,在文献中的描述也很有限。儿科急性护理从业者接触AWS的机会可能有限。我们报告了一例16岁男性病例,有多种物质滥用史,出现轻度AWS并迅速发展为震颤谵妄。他的戒断最初对高剂量苯二氮䓬类药物治疗无效,但对苯巴比妥反应良好。该病例凸显了如果不积极治疗,AWS会发展得多么迅速和危险。鉴于青少年酒精使用的增加以及出现危及生命症状的可能性,从业者,尤其是急诊医学、重症监护和医院医学等急性护理专业的从业者,将受益于对AWS诊断和管理策略的更多了解。