International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330, Braga, Portugal.
Food Microbiol. 2023 Aug;113:104251. doi: 10.1016/j.fm.2023.104251. Epub 2023 Mar 9.
The viability of SARS-CoV-2 on food surfaces and its propagation through the food chain has been discussed by several stakeholders, as it may represent a serious public health problem, bringing new challenges to the food system. This work shows for the first time that edible films can be used against SARS-CoV-2. Sodium alginate-based films containing gallic acid, geraniol, and green tea extract were evaluated in terms of their antiviral activity against SARS-CoV-2. The results showed that all these films have strong in vitro antiviral activity against this virus. However, a higher concentration of the active compound (1.25%) is needed for the film containing gallic acid to achieve similar results to those obtained for lower concentrations of geraniol and green tea extract (0.313%). Furthermore, critical concentrations of the active compounds in the films were used to evaluate their stability during storage. Results showed that gallic acid-loaded films lose their activity from the second week of storage, while films with geraniol and green tea extract only show a drop in activity after four weeks. These results highlight the possibility of using edible films and coatings as antiviral materials on food surfaces or food contact materials, which may help to reduce the spreading of viruses through the food chain.
SARS-CoV-2 在食物表面的存活及其通过食物链传播的问题已引起了多方关注，因为这可能会对公共卫生造成严重影响，给食品系统带来新的挑战。本研究首次表明，可食用薄膜可用于对抗 SARS-CoV-2。评估了含有没食子酸、香叶醇和绿茶提取物的海藻酸钠薄膜在抗病毒方面针对 SARS-CoV-2 的活性。结果表明，所有这些薄膜对该病毒均具有很强的体外抗病毒活性。但是，对于含有没食子酸的薄膜，需要更高浓度的活性化合物（1.25％）才能达到与香叶醇和绿茶提取物的较低浓度（0.313％）相似的效果。此外，使用薄膜中活性化合物的临界浓度来评估其在储存过程中的稳定性。结果表明，负载没食子酸的薄膜在储存的第二周开始失去活性，而含有香叶醇和绿茶提取物的薄膜在四周后才显示出活性下降。这些结果突出了在食物表面或食品接触材料上使用可食用薄膜和涂料作为抗病毒材料的可能性，这可能有助于减少病毒通过食物链的传播。
