Department of Biology, Queen's University, Kingston, ON K7L 3N6, Canada.
Int J Mol Sci. 2023 Apr 9;24(8):6963. doi: 10.3390/ijms24086963.
MicroRNAs are critical regulators of post-transcriptional gene expression in a wide range of taxa, including invertebrates, mammals, and plants. Since their discovery in the nematode, miRNA research has exploded, and they are being identified in almost every facet of development. Invertebrate model organisms, particularly and , are ideal systems for studying miRNA function, and the roles of many miRNAs are known in these animals. In this review, we compiled the functions of many of the miRNAs that are involved in the development of these invertebrate model species. We examine how gene regulation by miRNAs shapes both embryonic and larval development and show that, although many different aspects of development are regulated, several trends are apparent in the nature of their regulation.
微小 RNA 是广泛生物类群（包括无脊椎动物、哺乳动物和植物）中转录后基因表达的关键调控因子。自在线虫中发现微小 RNA 以来，微小 RNA 研究蓬勃发展，几乎在发育的各个方面都能鉴定到微小 RNA。无脊椎动物模式生物，特别是 和 ，是研究微小 RNA 功能的理想系统，这些动物中的许多微小 RNA 的作用已被阐明。在这篇综述中，我们汇集了参与这些无脊椎动物模式物种发育的许多微小 RNA 的功能。我们研究了微小 RNA 对基因的调控如何塑造胚胎和幼虫发育，并表明，尽管许多不同的发育方面受到调控，但在其调控的性质上存在几个明显的趋势。
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