肥大细胞在某些皮肤疾病中炎症的诱导和维持中的作用。
The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases.
机构信息
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, The University of Warmia and Mazury, 10-229 Olsztyn, Poland.
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, Poland.
出版信息
Int J Mol Sci. 2023 Apr 10;24(8):7021. doi: 10.3390/ijms24087021.
Under physiological conditions, skin mast cells play an important role as guardians that quickly react to stimuli that disturb homeostasis. These cells efficiently support, fight infection, and heal the injured tissue. The substances secreted by mast cells allow for communication inside the body, including the immune, nervous, and blood systems. Pathologically non-cancerous mast cells participate in allergic processes but also may promote the development of autoinflammatory or neoplastic disease. In this article, we review the current literature regarding the role of mast cells in autoinflammatory, allergic, neoplastic skin disease, as well as the importance of these cells in systemic diseases with a pronounced course with skin symptoms.
在生理条件下，皮肤肥大细胞作为守护者发挥着重要作用，它们能迅速对扰乱内稳态的刺激做出反应。这些细胞有效地支持、抗感染和修复受损组织。肥大细胞分泌的物质允许体内进行通讯，包括免疫、神经和血液系统。病理性非癌性肥大细胞参与过敏过程，但也可能促进自身炎症性或肿瘤性疾病的发展。本文综述了肥大细胞在自身炎症性、过敏性、肿瘤性皮肤疾病中的作用，以及这些细胞在伴有明显皮肤症状的系统性疾病中的重要性。
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