人类内源性逆转录病毒、SARS-CoV-2 和 HIV 通过炎症和生长刺激促进 PAH。
Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation.
机构信息
Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Division of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, IN 46202, USA.
出版信息
Int J Mol Sci. 2023 Apr 18;24(8):7472. doi: 10.3390/ijms24087472.
Pulmonary arterial hypertension (PAH) is a pulmonary vascular disease characterized by the progressive elevation of pulmonary arterial pressures. It is becoming increasingly apparent that inflammation contributes to the pathogenesis and progression of PAH. Several viruses are known to cause PAH, such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human endogenous retrovirus K(HERV-K), and human immunodeficiency virus (HIV), in part due to acute and chronic inflammation. In this review, we discuss the connections between HERV-K, HIV, SARS-CoV-2, and PAH, to stimulate research regarding new therapeutic options and provide new targets for the treatment of the disease.
肺动脉高压（PAH）是一种肺血管疾病，其特征是肺动脉压逐渐升高。越来越明显的是，炎症有助于 PAH 的发病机制和进展。有几种病毒已知可导致 PAH，例如严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）、人类内源性逆转录病毒 K（HERV-K）和人类免疫缺陷病毒（HIV），部分原因是急性和慢性炎症。在这篇综述中，我们讨论了 HERV-K、HIV、SARS-CoV-2 和 PAH 之间的联系，以激发有关新治疗选择的研究，并为该疾病的治疗提供新的靶点。
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