Suppr超能文献

癫痫的现状与挑战——一篇叙述性综述

State of the Art and Challenges in Epilepsy-A Narrative Review.

作者信息

Manole Aida Mihaela, Sirbu Carmen Adella, Mititelu Mihaela Raluca, Vasiliu Octavian, Lorusso Lorenzo, Sirbu Octavian Mihai, Ionita Radu Florentina

机构信息

Department of Neurology, 'Dr. Carol Davila' Central Military Emergency University Hospital, 010242 Bucharest, Romania.

Clinical Neurosciences Department, University of Medicine and Pharmacy "Carol Davila" Bucharest, 050474 Bucharest, Romania.

出版信息

J Pers Med. 2023 Apr 1;13(4):623. doi: 10.3390/jpm13040623.

Abstract

Epilepsy is a common condition worldwide, with approximately 50 million people suffering from it. A single seizure does not mean epilepsy; almost 10% of the population can have a seizure during their lifetime. In particular, there are many other central nervous system disorders other than epilepsy in which seizures occur, either transiently or as a comorbid condition. The impact of seizures and epilepsy is, therefore, widespread and easily underestimated. It is estimated that about 70% of patients with epilepsy could be seizure-free if correctly diagnosed and treated. However, for patients with epilepsy, quality of life is influenced not only by seizure control but also by antiepileptic drug-adverse reactions, access to education, mood, employment, and transportation.

摘要

癫痫在全球是一种常见病症,约有5000万人受其困扰。单次发作并不意味着患有癫痫;几乎10%的人口在其一生中会有一次发作。特别是,除癫痫外还有许多其他中枢神经系统疾病会出现发作,发作可能是短暂的,也可能是作为一种合并症出现。因此,发作和癫痫的影响广泛且容易被低估。据估计,如果正确诊断和治疗,约70%的癫痫患者可以无发作。然而,对于癫痫患者来说,生活质量不仅受发作控制的影响,还受抗癫痫药物不良反应、受教育机会、情绪、就业和交通等因素的影响。

相似文献

1
State of the Art and Challenges in Epilepsy-A Narrative Review.
J Pers Med. 2023 Apr 1;13(4):623. doi: 10.3390/jpm13040623.
2
Surgical management of medically refractory epilepsy due to early childhood stroke.
J Neurosurg Pediatr. 2014 Jul;14(1):58-67. doi: 10.3171/2014.3.PEDS13440. Epub 2014 May 9.
3
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.
Cochrane Database Syst Rev. 2018 Aug 9;8(8):CD001769. doi: 10.1002/14651858.CD001769.pub4.
4
Treatments for seizures in catamenial (menstrual-related) epilepsy.
Cochrane Database Syst Rev. 2019 Oct 14;10(10):CD013225. doi: 10.1002/14651858.CD013225.pub2.
5
Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
Cochrane Database Syst Rev. 2019 Jul 18;7(7):CD001911. doi: 10.1002/14651858.CD001911.pub4.
6
Epilepsy in patients with primary brain tumors: The impact on mood, cognition, and HRQOL.
Epilepsy Behav. 2015 Jul;48:88-95. doi: 10.1016/j.yebeh.2015.03.016. Epub 2015 Jun 29.
7
Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
Cochrane Database Syst Rev. 2018 Oct 23;10(10):CD003615. doi: 10.1002/14651858.CD003615.pub4.
8
Yoga for epilepsy.
Cochrane Database Syst Rev. 2017 Oct 5;10(10):CD001524. doi: 10.1002/14651858.CD001524.pub3.
9
Treatments for seizures in catamenial (menstrual-related) epilepsy.
Cochrane Database Syst Rev. 2021 Sep 16;9(9):CD013225. doi: 10.1002/14651858.CD013225.pub3.

引用本文的文献

2
Clinical characterization and management of persons with comorbid epilepsy and depression: an expert opinion paper.
Front Pharmacol. 2025 Jul 1;16:1592650. doi: 10.3389/fphar.2025.1592650. eCollection 2025.
5
Effect of solid lipid nanoparticles loaded with valproate and metformin on pentylenetetrazole-induced epilepsy in rats.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 5. doi: 10.1007/s00210-025-03983-6.
6
Global, regional, and national burden of epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Lancet Public Health. 2025 Mar;10(3):e203-e227. doi: 10.1016/S2468-2667(24)00302-5. Epub 2025 Feb 24.
7
Development, and characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach.
Drug Deliv. 2025 Dec;32(1):2460693. doi: 10.1080/10717544.2025.2460693. Epub 2025 Feb 3.
9
Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy.
Brain Sci. 2024 Jan 10;14(1):71. doi: 10.3390/brainsci14010071.
10
Anti-seizure Medications: Challenges and Opportunities.
CNS Neurol Disord Drug Targets. 2024;23(9):1120-1133. doi: 10.2174/0118715273275793231030060833.

本文引用的文献

1
Air Pollution and Its Devastating Effects on the Central Nervous System.
Healthcare (Basel). 2022 Jun 23;10(7):1170. doi: 10.3390/healthcare10071170.
2
Ambient air pollution and epileptic seizures: A panel study in Australia.
Epilepsia. 2022 Jul;63(7):1682-1692. doi: 10.1111/epi.17253. Epub 2022 Apr 26.
3
Approach to the Medical Treatment of Epilepsy.
Continuum (Minneap Minn). 2022 Apr 1;28(2):483-499. doi: 10.1212/CON.0000000000001081.
4
Multidisciplinary Care of Patients with Inherited Metabolic Diseases and Epilepsy: Current Perspectives.
J Multidiscip Healthc. 2022 Mar 25;15:553-566. doi: 10.2147/JMDH.S251863. eCollection 2022.
6
Genetic testing for the epilepsies: A systematic review.
Epilepsia. 2022 Feb;63(2):375-387. doi: 10.1111/epi.17141. Epub 2021 Dec 10.
7
Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice.
Epilepsy Behav. 2020 Mar;104(Pt A):106939. doi: 10.1016/j.yebeh.2020.106939. Epub 2020 Feb 10.
8
Counseling and Management of the Risks of Living With Epilepsy.
Continuum (Minneap Minn). 2019 Apr;25(2):477-491. doi: 10.1212/CON.0000000000000708.
9
Epilepsy Emergencies: Status Epilepticus, Acute Repetitive Seizures, and Autoimmune Encephalitis.
Continuum (Minneap Minn). 2019 Apr;25(2):454-476. doi: 10.1212/CON.0000000000000716.
10
Optimizing Management of Medically Responsive Epilepsy.
Continuum (Minneap Minn). 2019 Apr;25(2):343-361. doi: 10.1212/CON.0000000000000709.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验