Rizzi Angela, Gammeri Luca, Cordiano Raffaele, Valentini Mariagrazia, Centrone Michele, Marrone Sabino, Inchingolo Riccardo, Lohmeyer Franziska Michaela, Cavaliere Carlo, Ria Francesco, Cadoni Gabriella, Gangemi Sebastiano, Nucera Eleonora
UOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy.
J Clin Med. 2023 Apr 13;12(8):2841. doi: 10.3390/jcm12082841.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, which is typically characterized by a Type 2 inflammatory reaction, comorbidities and high rates of nasal polyp recurrence, causing severe impact on quality of life. Nasal polyp recurrence rates, defined as the number of patients undergoing revision endoscopic sinus surgery, are 20% within a 5 year period after surgery. The cornerstone of CRSwNP management consists of anti-inflammatory treatment with local corticosteroids. We performed a literature review regarding the therapeutic strategies used to prevent nasal polyp recurrence after surgical treatment. Finally, we report an in vitro study evaluating the efficacy of lysine-acetylsalicylic acid and other non-steroidal anti-inflammatory drugs (ketoprofen and diclofenac) on the proliferation of fibroblasts, obtained from nasal polyp tissue samples. Our study demonstrates that diclofenac, even more so than lysine-acetylsalicylic acid, significantly inhibits fibroblast proliferation and could be considered a valid therapeutic strategy in preventing CRSwNP recurrence.
伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）是慢性鼻-鼻窦炎最令人困扰的表型，其典型特征为2型炎症反应、合并症以及鼻息肉高复发率，对生活质量造成严重影响。鼻息肉复发率定义为接受内镜鼻窦修正手术的患者数量，术后5年内的复发率为20%。CRSwNP治疗的基石包括局部使用糖皮质激素进行抗炎治疗。我们对手术治疗后预防鼻息肉复发所采用的治疗策略进行了文献综述。最后，我们报告了一项体外研究，评估赖氨酸-乙酰水杨酸及其他非甾体抗炎药（酮洛芬和双氯芬酸）对从鼻息肉组织样本中获取的成纤维细胞增殖的影响。我们的研究表明，双氯芬酸比赖氨酸-乙酰水杨酸更能显著抑制成纤维细胞增殖，可被视为预防CRSwNP复发的有效治疗策略。
