• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

有机催化与生物催化的完美结合：辅因子类似物在不对称合成中的潜在应用。

Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis.

机构信息

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.

出版信息

J Org Chem. 2023 Jun 16;88(12):7619-7629. doi: 10.1021/acs.joc.2c02747. Epub 2023 Apr 26.

DOI:10.1021/acs.joc.2c02747
PMID:37126859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10278144/
Abstract

Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis.

摘要

许多酶与小分子辅因子协同工作，这启发了有机催化剂的设计。辅因子支架的化学修饰提高了有机催化的反应活性和反应范围。这篇综述介绍了在有机催化和生物催化中使用辅因子（天然和模拟物）的一些最新进展。我们旨在强调结合生物催化和有机催化中获得的基础知识来进行不对称生物催化的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/dcb24d31d6ad/jo2c02747_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/25dfade140db/jo2c02747_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/dc186e18f737/jo2c02747_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/4346b4dc090e/jo2c02747_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/713b5eb0bca8/jo2c02747_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/91fbc229b086/jo2c02747_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/19cc5ab34fef/jo2c02747_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c7091ad15b16/jo2c02747_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/e56051d40baa/jo2c02747_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/91f14dcf9d19/jo2c02747_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c6836e2a64e2/jo2c02747_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c210cc66ab79/jo2c02747_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/93341f5c93b3/jo2c02747_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/631343d5b1f2/jo2c02747_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/08f4cf97c2b3/jo2c02747_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/dcb24d31d6ad/jo2c02747_0015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/25dfade140db/jo2c02747_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/dc186e18f737/jo2c02747_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/4346b4dc090e/jo2c02747_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/713b5eb0bca8/jo2c02747_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/91fbc229b086/jo2c02747_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/19cc5ab34fef/jo2c02747_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c7091ad15b16/jo2c02747_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/e56051d40baa/jo2c02747_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/91f14dcf9d19/jo2c02747_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c6836e2a64e2/jo2c02747_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/c210cc66ab79/jo2c02747_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/93341f5c93b3/jo2c02747_0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/631343d5b1f2/jo2c02747_0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/08f4cf97c2b3/jo2c02747_0014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89c1/10278144/dcb24d31d6ad/jo2c02747_0015.jpg

相似文献

1
Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis.有机催化与生物催化的完美结合：辅因子类似物在不对称合成中的潜在应用。
J Org Chem. 2023 Jun 16;88(12):7619-7629. doi: 10.1021/acs.joc.2c02747. Epub 2023 Apr 26.
2
Unlocking New Reactivities in Enzymes by Iminium Catalysis.通过亚胺催化解锁酶的新反应活性。
Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202203613. doi: 10.1002/anie.202203613. Epub 2022 Jun 15.
3
Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes.天然有机催化辅因子和人工有机催化辅因子的衍生物作为酶中的催化剂。
Chembiochem. 2022 Jul 5;23(13):e202100599. doi: 10.1002/cbic.202100599. Epub 2022 Apr 1.
4
Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes to create new catalysts.化学模拟生物催化：利用辅酶依赖酶的合成潜力创造新的催化剂。
J Am Chem Soc. 2015 Nov 11;137(44):13992-4006. doi: 10.1021/jacs.5b09348. Epub 2015 Nov 3.
5
The CoFactor database: organic cofactors in enzyme catalysis.辅因子数据库：酶催化中的有机辅因子。
Bioinformatics. 2010 Oct 1;26(19):2496-7. doi: 10.1093/bioinformatics/btq442. Epub 2010 Aug 2.
6
Co-immobilized Phosphorylated Cofactors and Enzymes as Self-Sufficient Heterogeneous Biocatalysts for Chemical Processes.共固定化磷酸化辅因子和酶作为自给自足的非均相生物催化剂用于化学过程。
Angew Chem Int Ed Engl. 2017 Jan 16;56(3):771-775. doi: 10.1002/anie.201609758. Epub 2016 Dec 21.
7
Application of Biobased Solvents in Asymmetric Catalysis.生物基溶剂在不对称催化中的应用。
Molecules. 2022 Oct 8;27(19):6701. doi: 10.3390/molecules27196701.
8
Catalysing (organo-)catalysis: Trends in the application of machine learning to enantioselective organocatalysis.催化（有机）催化：机器学习在对映选择性有机催化中的应用趋势
Beilstein J Org Chem. 2024 Sep 10;20:2280-2304. doi: 10.3762/bjoc.20.196. eCollection 2024.
9
Recent advances in organocatalytic methods for asymmetric C-C bond formation.有机催化不对称 C-C 键形成方法的最新进展。
Chemistry. 2013 Oct 18;19(43):14346-96. doi: 10.1002/chem.201301996. Epub 2013 Sep 20.
10
Asymmetric organocatalysis combined with metal catalysis: concept, proof of concept, and beyond.不对称有机催化与金属催化的结合：概念、概念验证及超越。
Acc Chem Res. 2014 Aug 19;47(8):2365-77. doi: 10.1021/ar500101a. Epub 2014 Jun 9.

引用本文的文献

1
Pyridoxal-Inspired Photo-Decarboxylase Catalysis: Photochemical Decarboxylation of Unprotected Amino Acids.基于吡哆醛的光脱羧酶催化作用：未保护氨基酸的光化学脱羧反应
Angew Chem Int Ed Engl. 2025 Apr 1;64(14):e202424843. doi: 10.1002/anie.202424843. Epub 2025 Feb 25.
2
Installation of an organocatalyst into a protein scaffold creates an artificial Stetterase.将有机催化剂安装到蛋白质支架中会产生人工 Stetterase。
Chem Commun (Camb). 2024 Nov 19;60(93):13746-13749. doi: 10.1039/d4cc05182c.
3
Nature-Inspired Radical Pyridoxal-Mediated C-C Bond Formation.

本文引用的文献

1
Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes.天然有机催化辅因子和人工有机催化辅因子的衍生物作为酶中的催化剂。
Chembiochem. 2022 Jul 5;23(13):e202100599. doi: 10.1002/cbic.202100599. Epub 2022 Apr 1.
2
Asymmetric biomimetic transamination of α-keto amides to peptides.不对称仿生转氨基反应将α-酮酰胺转化为肽。
Nat Commun. 2021 Aug 30;12(1):5174. doi: 10.1038/s41467-021-25449-y.
3
Flavin-dependent halogenases catalyze enantioselective olefin halocyclization.黄素依赖卤代酶催化对映选择性烯烃卤环化反应。
受自然启发的自由基吡哆醛介导的C-C键形成
J Am Chem Soc. 2024 Aug 21;146(33):23321-23329. doi: 10.1021/jacs.4c05997. Epub 2024 Aug 6.
4
De-epimerizing DyKAT of β-lactones generated by isothiourea-catalysed enantioselective [2 + 2] cycloaddition.异硫脲催化的对映选择性[2 + 2]环加成反应生成的β-内酯的去差向异构化DyKAT反应
Chem Sci. 2024 Apr 24;15(23):8896-8904. doi: 10.1039/d4sc01410c. eCollection 2024 Jun 12.
5
Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems.利用生物催化系统合成代谢物及类代谢物化合物
Metabolites. 2023 Oct 19;13(10):1097. doi: 10.3390/metabo13101097.
Nat Commun. 2021 Jun 1;12(1):3268. doi: 10.1038/s41467-021-23503-3.
4
Catalytic Principles from Natural Enzymes and Translational Design Strategies for Synthetic Catalysts.天然酶的催化原理与合成催化剂的转化设计策略
ACS Cent Sci. 2021 Jan 27;7(1):72-80. doi: 10.1021/acscentsci.0c01556. Epub 2020 Dec 19.
5
Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts.链霉亲和素负载的仲胺有机催化剂催化的转移氢化反应。
Chem Commun (Camb). 2021 Feb 23;57(15):1919-1922. doi: 10.1039/d0cc08142f.
6
Kinetic and structure-activity studies of the triazolium ion-catalysed benzoin condensation.三唑鎓离子催化苯偶姻缩合的动力学和构效关系研究。
Org Biomol Chem. 2021 Jan 21;19(2):387-393. doi: 10.1039/d0ob02207a.
7
Advances in asymmetric organocatalysis over the last 10 years.过去 10 年中不对称有机催化的进展。
Nat Commun. 2020 Jul 29;11(1):3786. doi: 10.1038/s41467-020-17580-z.
8
Tryptophan Synthase: Biocatalyst Extraordinaire.色氨酸合酶：非凡的生物催化剂。
Chembiochem. 2021 Jan 5;22(1):5-16. doi: 10.1002/cbic.202000379. Epub 2020 Sep 22.
9
Streptavidin-Hosted Organocatalytic Aldol Addition.链霉亲和素介导的有机催化Aldol 加成反应。
Molecules. 2020 May 25;25(10):2457. doi: 10.3390/molecules25102457.
10
Discovery and Biocatalytic Application of a PLP-Dependent Amino Acid γ-Substitution Enzyme That Catalyzes C-C Bond Formation.发现并生物催化应用一种依赖于吡哆醛（PLP）的氨基酸γ-取代酶，该酶能催化 C-C 键形成。
J Am Chem Soc. 2020 Jun 10;142(23):10506-10515. doi: 10.1021/jacs.0c03535. Epub 2020 Jun 1.