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基于F-FDG PET/CT的肌切开术和选择性周围神经去神经术治疗难治性颈部肌张力障碍:一例报告

Myotomy and Selective Peripheral Denervation Based on F-FDG PET/CT in Intractable Cervical Dystonia: A Case Report.

作者信息

Miura Isamu, Horisawa Shiro, Kawamata Takakazu, Taira Takaomi

机构信息

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

出版信息

NMC Case Rep J. 2023 Apr 10;10:99-102. doi: 10.2176/jns-nmc.2022-0392. eCollection 2023.

Abstract

Cervical dystonia, characterized by the involuntary contraction of cervical muscles, is the most common form of adult dystonia. In a patient with intractable cervical dystonia, we carried out a myotomy of the left obliquus capitis inferior and selective peripheral denervation (SPD) of the posterior branches of the C3-C6 spinal nerves based on preoperative 18F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT). The patient was a 65-year-old, right-handed man with an unremarkable medical history. His head rotated involuntarily to the left. Medication and botulinum toxin injections were ineffective, and surgical treatment was considered. F-FDG PET/CT imaging revealed FDG uptake in the left obliquus capitis inferior, right sternocleidomastoideus, and left splenius capitis. Myotomy of the left obliquus capitis inferior and SPD of the posterior branches of the C3-C6 spinal nerves was performed under general anesthesia. During the 6-month follow-up, the patient's Toronto Western Spasmodic Torticollis Rating Scale score improved from 35 to 9. This case shows that preoperative F-FDG PET/CT is effective in identifying dystonic muscles and determining the surgical strategy for cervical dystonia.

摘要

颈部肌张力障碍以颈部肌肉不自主收缩为特征,是成人肌张力障碍最常见的形式。对于一名患有顽固性颈部肌张力障碍的患者,我们基于术前18F-氟脱氧葡萄糖(F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT),对其左头下斜肌进行了肌切开术,并对C3-C6脊神经后支进行了选择性周围神经去神经术(SPD)。该患者为一名65岁的右利手男性,既往病史无特殊。他的头部不自主地向左旋转。药物治疗和肉毒杆菌毒素注射均无效,因此考虑进行手术治疗。F-FDG PET/CT成像显示左头下斜肌、右胸锁乳突肌和左头夹肌有FDG摄取。在全身麻醉下对左头下斜肌进行了肌切开术,并对C3-C6脊神经后支进行了SPD。在6个月的随访期间,患者的多伦多西部痉挛性斜颈评定量表评分从35分提高到了9分。该病例表明,术前F-FDG PET/CT在识别肌张力障碍肌肉和确定颈部肌张力障碍的手术策略方面是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3def/10149141/f14cbf4dc123/2188-4226-10-0099-g001.jpg

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