权衡抗肿瘤免疫与免疫检查点抑制剂引起的危及生命的心肌炎。
Weighing Antitumor Immunity against Life-threatening Myocarditis from Immune-Checkpoint Inhibitors.
机构信息
Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
出版信息
Cancer Discov. 2023 May 4;13(5):1040-1042. doi: 10.1158/2159-8290.CD-23-0199.
In this issue of Cancer Discovery, Salem and colleagues report a combination therapy for immune-checkpoint inhibitor (ICI) myocarditis using high-dose glucocorticoids, abatacept, and the JAK inhibitor ruxolitinib. The apparent efficacy of their strategy and an accompanying animal model provide further evidence for common immune mechanisms underlying ICI toxicities. See related article by Salem et al., p. 1100 (2).
在本期《癌症发现》杂志中，Salem 及其同事报告了一种免疫检查点抑制剂（ICI）心肌炎的联合治疗方案，该方案使用了大剂量糖皮质激素、阿巴西普和 JAK 抑制剂芦可替尼。他们的策略的明显疗效和一个伴随的动物模型为 ICI 毒性的共同免疫机制提供了进一步的证据。见 Salem 等人的相关文章，第 1100 页（2）。
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