妊娠期丙型肝炎病毒：检测和治疗的机会。
Hepatitis C Virus in Pregnancy: An Opportunity to Test and Treat.
机构信息
University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15213, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA; Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA.
出版信息
Obstet Gynecol Clin North Am. 2023 Jun;50(2):363-373. doi: 10.1016/j.ogc.2023.02.008.
With the advent of safe and well-tolerated direct-acting antiviral (DAA) medications for hepatitis C virus (HCV), disease eradication is on the horizon. However, as the rate of HCV infection among women of childbearing potential continues to rise due to the ongoing opioid epidemic in the United States, perinatal transmission of HCV presents an increasingly difficult barrier. Without the ability to treat HCV during pregnancy, complete eradication is unlikely. In this review, we discuss the current epidemiology of HCV in the United States, the current management strategy for HCV in pregnancy, as well as the potential for future use of DAAs in pregnancy.
随着安全且耐受良好的直接作用抗病毒（DAA）药物治疗丙型肝炎病毒（HCV）的出现，疾病的消除已指日可待。然而，由于美国阿片类药物流行持续存在，生育期妇女的 HCV 感染率不断上升，HCV 的围产期传播构成了越来越难以克服的障碍。如果在怀孕期间无法治疗 HCV，完全消除 HCV 感染就不太可能实现。在这篇综述中，我们讨论了美国 HCV 的当前流行病学情况、HCV 在怀孕期间的当前管理策略，以及 DAA 在怀孕期间的未来应用潜力。
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