铜(II)催化的香豆素-3-羧酸与 -丙炔醇原位生成的α,β-不饱和羰基化合物的脱羧（4 + 2）环加成反应。
Cu(II)-Catalyzed Decarboxylative (4 + 2) Annulation of Coumarin-3-Carboxylic Acids with In Situ Generated α,β-Unsaturated Carbonyl Compounds from -Propargylic Alcohols.
机构信息
School of Chemistry, University of Hyderabad, Hyderabad 500046, Telangana, India.
出版信息
Org Lett. 2023 May 19;25(19):3397-3401. doi: 10.1021/acs.orglett.3c00925. Epub 2023 May 8.
PMID:37154427
Abstract
Cu(II)-catalyzed decarboxylative oxidative (4 + 2) annulation of coumarin-3-carboxylic acids with -propargylic alcohols, via the in situ generated α,β-unsaturated carbonyl compounds by the Meyer-Schuster rearrangement, has been developed. This protocol involving indirect C-H functionalization offers access to diverse naphthochromenone architectures with good to excellent yields.
摘要
Cu(II)催化的香豆素-3-羧酸与 -丙炔醇的脱羧氧化（4 + 2）环加成反应，通过 Meyer-Schuster 重排由原位生成的α，β-不饱和羰基化合物引发，已经被开发出来。该方案涉及间接 C-H 官能化，可获得具有良好至优异收率的各种萘并色烯酮结构。
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