光学流比在冠心病患者中的诊断效能：一项荟萃分析。
Diagnostic efficacy of the optical flow ratio in patients with coronary heart disease: A meta-analysis.
机构信息
Medical College of Nanchang University, Nanchang, Jiangxi Province, China.
Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China.
出版信息
PLoS One. 2023 May 10;18(5):e0285508. doi: 10.1371/journal.pone.0285508. eCollection 2023.
BACKGROUND
Coronary atherosclerotic heart disease (CAD) remains one of the most serious diseases threatening human health and life. PCI (Percutaneous Coronary Intervention) is the most common treatment for patients with CAD. A rigorous and comprehensive assessment of coronary artery lesions is now needed before PCI, however, there is no consensus on how best evaluate the combination of various intracavitary imaging techniques. By merging the benefits of physiological assessment and high-definition imaging, the optical flow ratio (OFR) has emerged as a novel technology with promising prospects for application.
METHODS
A systematic review of the literature was conducted. Studies that met the criteria of the meta-analysis were considered to assess OFR and FFR (fractional flow reserve). And the summary values of sensitivity and specificity of diagnostic tests and summary receiver operating curves (SROC) were calculated.
RESULTS
A total of 5 studies were included. The sensitivity and specificity of OFR in the diagnosis of coronary artery lesions were 0.83 (95% CI: 0.75-0.88) and 0.94 (95% CI: 0.91-0.96), respectively; the positive likelihood ratio and the negative likelihood ratio were 14 (95% CI: 9.3, 21.3) and 0.18 (95% CI:0.13, 0.27), respectively. OFR showed good correlation and consistency with FFR.
CONCLUSION
The new OFR technique achieve an encouraging diagnostic performance, which also showed good correlation and consistency with FFR.
背景
冠状动脉粥样硬化性心脏病（CAD）仍然是威胁人类健康和生命的最严重疾病之一。经皮冠状动脉介入治疗（PCI）是 CAD 患者最常见的治疗方法。然而，在 PCI 之前，现在需要对冠状动脉病变进行严格和全面的评估，但对于如何最好地评估各种腔内成像技术的组合尚无共识。通过合并生理评估和高清成像的优势，血流比（OFR）作为一种具有应用前景的新技术出现了。
方法
进行了文献系统评价。被认为符合荟萃分析标准的研究被用来评估 OFR 和 FFR（血流储备分数）。并计算了诊断测试的汇总值的敏感性和特异性以及汇总受试者工作特征曲线（SROC）。
结果
共纳入 5 项研究。OFR 诊断冠状动脉病变的敏感性和特异性分别为 0.83（95%CI：0.75-0.88）和 0.94（95%CI：0.91-0.96）；阳性似然比和阴性似然比分别为 14（95%CI：9.3，21.3）和 0.18（95%CI：0.13，0.27）。OFR 与 FFR 具有良好的相关性和一致性。
结论
新的 OFR 技术具有令人鼓舞的诊断性能，与 FFR 也具有良好的相关性和一致性。
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