快照：真核核糖体生物发生 I.

SnapShot: Eukaryotic ribosome biogenesis I.

机构信息

Heidelberg University Biochemistry Center (BZH), Heidelberg, Germany.

Institutes of Biomedical Sciences, Fudan University, Shanghai, China.

出版信息

Cell. 2023 May 11;186(10):2282-2282.e1. doi: 10.1016/j.cell.2023.04.030.

DOI:10.1016/j.cell.2023.04.030

PMID:37172570

Abstract

Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits unravel the mechanisms of small ribosome synthesis. To view this SnapShot, open or download the PDF.

摘要

核糖体的产生对每个细胞都是至关重要的，其产生的失败会导致人类疾病。核糖体的产生是由大约 200 个组装因子沿着从核仁到细胞质的有序途径驱动的。从最早的 90S 前核糖体到成熟的 40S 亚基的生物发生中间体的结构快照揭示了小核糖体合成的机制。要查看此快照，请打开或下载 PDF。