School of Pharmacy, Zunyi Medical University, Zunyi 563000, China.
Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi 563003, China.
Int J Mol Sci. 2023 Apr 23;24(9):7731. doi: 10.3390/ijms24097731.
Despite the many strategies employed to slow the spread of cancer, the development of new anti-tumor drugs and the minimization of side effects have been major research hotspots in the anti-tumor field. Natural drugs are a huge treasure trove of drug development, and they have been widely used in the clinic as anti-tumor drugs. species in the family are widely distributed worldwide, and they have been well-documented in clinical practice for the prevention and treatment of cancer. Biflavonoids are the main active ingredients in , and they have good biological and anti-tumor activities, which warrant extensive research. The promise of biflavonoids from (SFB) in the field of cancer therapy is being realized thanks to new research that offers insights into the multi-targeting therapeutic mechanisms and key signaling pathways. The pharmacological effects of SFB against various cancers in vitro and in vivo are reviewed in this review. In addition, the types and characteristics of biflavonoid structures are described in detail; we also provide a brief summary of the efforts to develop drug delivery systems or combinations to enhance the bioavailability of SFB monomers. In conclusion, SFB species have great potential to be developed as adjuvant or even primary therapeutic agents for cancer, with promising applications.
尽管已经采取了许多策略来减缓癌症的传播，但开发新的抗肿瘤药物和最小化副作用一直是抗肿瘤领域的主要研究热点。天然药物是药物开发的巨大宝库，它们已被广泛应用于临床作为抗肿瘤药物。属中的种在世界范围内广泛分布，并且在癌症的预防和治疗方面已有充分的临床实践记录。双黄酮类化合物是 的主要活性成分，具有良好的生物活性和抗肿瘤活性，值得广泛研究。由于新的研究提供了对多靶点治疗机制和关键信号通路的深入了解，来自 （SFB）的双黄酮类化合物在癌症治疗领域的应用前景正在成为现实。本文综述了 SFB 在体外和体内对各种癌症的药理作用。此外，还详细描述了双黄酮类化合物结构的类型和特征；我们还简要总结了开发药物传递系统或组合以提高 SFB 单体生物利用度的努力。总之，SFB 物种具有作为癌症辅助甚至主要治疗剂的巨大潜力，具有广阔的应用前景。
