Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Department of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Front Immunol. 2023 Apr 26;14:1172931. doi: 10.3389/fimmu.2023.1172931. eCollection 2023.
Immunotherapy has revolutionized cancer treatment and revitalized efforts to harness the power of the immune system to combat a variety of cancer types more effectively. However, low clinical response rates and differences in outcomes due to variations in the immune landscape among patients with cancer continue to be major limitations to immunotherapy. Recent efforts to improve responses to immunotherapy have focused on targeting cellular metabolism, as the metabolic characteristics of cancer cells can directly influence the activity and metabolism of immune cells, particularly T cells. Although the metabolic pathways of various cancer cells and T cells have been extensively reviewed, the intersections among these pathways, and their potential use as targets for improving responses to immune-checkpoint blockade therapies, are not completely understood. This review focuses on the interplay between tumor metabolites and T-cell dysfunction as well as the relationship between several T-cell metabolic patterns and T-cell activity/function in tumor immunology. Understanding these relationships could offer new avenues for improving responses to immunotherapy on a metabolic basis.
免疫疗法已经彻底改变了癌症治疗，并重新激发了利用免疫系统的力量更有效地对抗各种癌症类型的努力。然而，癌症患者之间免疫景观的差异导致的低临床反应率和结果差异仍然是免疫疗法的主要限制。最近，为了提高免疫疗法的反应，人们一直致力于靶向细胞代谢，因为癌细胞的代谢特征可以直接影响免疫细胞，特别是 T 细胞的活性和代谢。尽管已经广泛综述了各种癌细胞和 T 细胞的代谢途径，但这些途径之间的交集及其作为改善免疫检查点阻断疗法反应的靶点的潜在用途尚不完全清楚。这篇综述重点讨论了肿瘤代谢物与 T 细胞功能障碍之间的相互作用以及几种 T 细胞代谢模式与肿瘤免疫学中 T 细胞活性/功能之间的关系。了解这些关系可以为基于代谢的改善免疫疗法反应提供新途径。
