Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.
College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China.
Gut Microbes. 2023 Jan-Dec;15(1):2206505. doi: 10.1080/19490976.2023.2206505.
The maternal microbiome is essential for the healthy growth and development of offspring and has long-term effects later in life. Recent advances indicate that the maternal microbiome begins to regulate fetal health and development during pregnancy. Furthermore, the maternal microbiome continues to affect early microbial colonization via birth and breastfeeding. Compelling evidence indicates that the maternal microbiome is involved in the regulation of immune and brain development and affects the risk of related diseases. Modulating offspring development by maternal diet and probiotic intervention during pregnancy and breastfeeding could be a promising therapy in the future. In this review, we summarize and discuss the current understanding of maternal microbiota development, perinatal microbial metabolite transfer, mother-to-infant microbial transmission during/after birth and its association with immune and brain development as well as corresponding diseases.
母体微生物组对于后代的健康成长和发育至关重要，并且会对其以后的生活产生长期影响。最近的研究进展表明，母体微生物组在怀孕期间开始调节胎儿的健康和发育。此外，母体微生物组通过分娩和母乳喂养继续影响早期微生物定植。大量证据表明，母体微生物组参与免疫和大脑发育的调节，并影响相关疾病的风险。在怀孕期间和母乳喂养期间通过母体饮食和益生菌干预来调节后代的发育可能是未来有前途的治疗方法。在这篇综述中，我们总结和讨论了目前对母体微生物群发育、围产期微生物代谢产物转移、分娩前后母婴微生物传播及其与免疫和大脑发育以及相应疾病的关联的理解。
