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多酚辅助组装金沉积聚乳酸微针用于 SERS 传感和抗菌光动力治疗。

Polyphenol-assisted assembly of Au-deposited polylactic acid microneedles for SERS sensing and antibacterial photodynamic therapy.

机构信息

Department of Photonics, National Cheng Kung University, Tainan 70101, Taiwan.

Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan.

出版信息

Chem Commun (Camb). 2023 May 23;59(42):6339-6342. doi: 10.1039/d3cc00733b.

Abstract

3D SERS microneedles with self-assembled AuNPs were fabricated with tannic acid (chemical glue and reductant) on polylactic acid microneedles for in-depth chemical and biomolecular analysis, with LOD values below 200 ppb for small molecules and 10 CFU cm for bacteria. The MB/Au-microneedles were used for photodynamic therapy with SERS-monitored photosensitizer degradation.

摘要

采用单宁酸(化学胶和还原剂)在聚乳酸微针上自组装金纳米粒子,制备了 3D SERS 微针,用于深入的化学和生物分子分析,小分子的 LOD 值低于 200 ppb,细菌的 LOD 值低于 10 CFU cm。MB/Au 微针用于光动力学治疗,通过 SERS 监测光敏剂降解。

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