Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Org Lett. 2023 May 26;25(20):3591-3595. doi: 10.1021/acs.orglett.3c00535. Epub 2023 May 16.
A methodology for the construction of sterically congested quaternary centers via the trapping of vinyl carbocations with silyl ketene acetals is disclosed. This main group-catalyzed α-vinylation reaction is advantageous as methods to access these congested motifs are limited. Moreover, β,γ-unsaturated carbonyl moieties and tetrasubstituted alkenes are present in various bioactive natural products and pharmaceuticals, and this catalytic platform offers a means of accessing them using simple and inexpensive materials.
本文公开了一种通过硅基烯酮缩醛捕获乙烯基碳正离子来构建空间位阻季碳原子的方法。这种主族催化的α-乙烯基化反应具有优势，因为获得这些拥挤结构的方法有限。此外，β,γ-不饱和羰基部分和四取代烯烃存在于各种生物活性天然产物和药物中，这种催化平台提供了一种使用简单廉价的材料来获得它们的方法。
Zotero 插件
