Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University, Beijing, China.
Aging Dis. 2023 Dec 1;14(6):2153-2166. doi: 10.14336/AD.2023.0226-1.
Endothelial cells, which are highly dynamic cells essential to the vascular network, play an indispensable role in maintaining the normal function of the body. Several lines of evidence indicate that the phenotype associated with senescent endothelial cells causes or promotes some neurological disorders. In this review, we first discuss the phenotypic changes associated with endothelial cell senescence; subsequently, we provide an overview of the molecular mechanisms of endothelial cell senescence and its relationship with neurological disorders. For refractory neurological diseases such as stroke and atherosclerosis, we intend to provide some valid clues and new directions for clinical treatment options.
内皮细胞是血管网络中至关重要的高度动态细胞，对于维持身体的正常功能起着不可或缺的作用。有几条证据表明，与衰老内皮细胞相关的表型会导致或促进某些神经障碍。在这篇综述中，我们首先讨论了与内皮细胞衰老相关的表型变化；随后，我们概述了内皮细胞衰老的分子机制及其与神经障碍的关系。对于诸如中风和动脉粥样硬化等难治性神经疾病，我们旨在为临床治疗选择提供一些有效的线索和新方向。
