Electrical Engineering Division, University of Cambridge, Cambridge, CB3 0FA, UK.
POLYMAT, University of the Basque Country UPV/EHU, Avda. Tolosa 72, Donostia-San Sebastian, Gipuzkoa, 20018, Spain.
Adv Sci (Weinh). 2024 Jul;11(27):e2301176. doi: 10.1002/advs.202301176. Epub 2023 May 18.
Electrocardiography imaging (ECGi) is a non-invasive inverse reconstruction procedure which employs body surface potential maps (BSPM) obtained from surface electrode array measurements to improve the spatial resolution and interpretability of conventional electrocardiography (ECG) for the diagnosis of cardiac dysfunction. ECGi currently lacks precision, which has prevented its adoption in clinical setups. The introduction of high-density electrode arrays could increase ECGi reconstruction accuracy but is not attempted before due to manufacturing and processing limitations. Advances in multiple fields have now enabled the implementation of such arrays which poses questions on optimal array design parameters for ECGi. In this work, a novel conducting polymer electrode manufacturing process on flexible substrates is proposed to achieve high-density, mm-sized, conformable, long-term, and easily attachable electrode arrays for BSPM with parameters optimally selected for ECGi applications. Temporal, spectral, and correlation analysis are performed on a prototype array demonstrating the validity of the chosen parameters and the feasibility of high-density BSPM, paving the way for ECGi devices fit for clinical application.
心电图成象术(ECGi)是一种非侵入性的反演重建过程,它利用从体表电极阵列测量获得的体表电位图(BSPM)来提高传统心电图(ECG)的空间分辨率和可解释性,从而诊断心脏功能障碍。目前,ECGi 缺乏精度,这阻碍了它在临床环境中的应用。高密度电极阵列的引入可以提高 ECGi 重建的准确性,但由于制造和处理的限制,以前没有尝试过。多个领域的进步现在已经使这种阵列的实现成为可能,这就提出了用于 ECGi 的最佳阵列设计参数的问题。在这项工作中,提出了一种在柔性衬底上制造导电聚合物电极的新方法,以实现高密度、毫米级、贴合、长期和易于附着的电极阵列,用于 BSPM,其参数经过优化选择,适用于 ECGi 应用。对原型阵列进行了时间、频谱和相关分析,证明了所选参数的有效性和高密度 BSPM 的可行性,为适合临床应用的 ECGi 设备铺平了道路。