化学方法揭示分枝杆菌的生物学。
Chemical approaches to unraveling the biology of mycobacteria.
机构信息
Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
出版信息
Cell Chem Biol. 2023 May 18;30(5):420-435. doi: 10.1016/j.chembiol.2023.04.014.
Mycobacterium tuberculosis (Mtb), perhaps more than any other organism, is intrinsically appealing to chemical biologists. Not only does the cell envelope feature one of the most complex heteropolymers found in nature but many of the interactions between Mtb and its primary host (we humans) rely on lipid and not protein mediators. Many of the complex lipids, glycolipids, and carbohydrates biosynthesized by the bacterium still have unknown functions, and the complexity of the pathological processes by which tuberculosis (TB) disease progress offers many opportunities for these molecules to influence the human response. Because of the importance of TB in global public health, chemical biologists have applied a wide-ranging array of techniques to better understand the disease and improve interventions.
结核分枝杆菌（Mtb）也许比其他任何生物体都更能吸引化学生物学家。不仅细胞包膜具有自然界中发现的最复杂的杂聚物之一，而且 Mtb 与其主要宿主（我们人类）之间的许多相互作用依赖于脂质而不是蛋白质介质。该细菌合成的许多复杂脂质、糖脂和碳水化合物的功能仍然未知，结核病（TB）疾病进展的病理过程的复杂性为这些分子影响人类反应提供了许多机会。由于 TB 在全球公共卫生中的重要性，化学生物学家已经应用了广泛的技术来更好地了解该疾病并改进干预措施。
Zotero 插件