Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China.
Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Naples, Italy.
Front Immunol. 2023 May 8;14:1128190. doi: 10.3389/fimmu.2023.1128190. eCollection 2023.
Cytokines and receptors of the IL-1 family are key mediators in innate immune and inflammatory reactions in physiological defensive conditions, but are also significantly involved in immune-mediated inflammatory diseases. Here, we will address the role of cytokines of the IL-1 superfamily and their receptors in neuroinflammatory and neurodegenerative diseases, in particular Multiple Sclerosis and Alzheimer's disease. Notably, several members of the IL-1 family are present in the brain as tissue-specific splice variants. Attention will be devoted to understanding whether these molecules are involved in the disease onset or are effectors of the downstream degenerative events. We will focus on the balance between the inflammatory cytokines IL-1β and IL-18 and inhibitory cytokines and receptors, in view of future therapeutic approaches.
细胞因子和白细胞介素-1 家族的受体是生理防御条件下固有免疫和炎症反应的关键介质，但它们也显著参与免疫介导的炎症性疾病。在这里，我们将讨论白细胞介素-1 超家族的细胞因子及其受体在神经炎症和神经退行性疾病中的作用，特别是多发性硬化症和阿尔茨海默病。值得注意的是，白细胞介素-1 家族的几个成员作为组织特异性剪接变体存在于大脑中。我们将关注这些分子是否参与疾病的发生，或者是否是下游退行性事件的效应物。鉴于未来的治疗方法，我们将重点关注炎症细胞因子白细胞介素-1β和白细胞介素-18 与抑制性细胞因子和受体之间的平衡。
