Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
Fundamental Research, Omya International AG, Froschackerstrasse 6, CH-4622 Egerkingen, Switzerland.
Eur J Pharm Biopharm. 2023 Aug;189:133-151. doi: 10.1016/j.ejpb.2023.05.019. Epub 2023 May 23.
Porous materials are ubiquitous and exhibit properties suitable for depositing therapeutic compounds. Drug loading in porous materials can protect the drug, control its release rate, and improve its solubility. However, to achieve such outcomes from porous delivery systems, effective incorporation of the drug in the internal porosity of the carrier must be guaranteed. Mechanistic knowledge of the factors influencing drug loading and release from porous carriers allows rational design of formulations by selecting a suitable carrier for each application. Much of this knowledge exists in research areas other than drug delivery. Thus, a comprehensive overview of this topic from the drug delivery aspect is warranted. This review aims to identify the loading processes and carrier characteristics influencing the drug delivery outcome with porous materials. Additionally, the kinetics of drug release from porous materials are elucidated, and the common approaches to mathematical modeling of these processes are outlined.
多孔材料无处不在，具有适合沉积治疗化合物的特性。在多孔材料中加载药物可以保护药物、控制其释放速度并提高其溶解度。然而，要从多孔递药系统中获得这样的效果，必须保证药物有效地掺入载体的内部孔隙中。对影响多孔载体中药物加载和释放的因素的机理知识，可以通过为每种应用选择合适的载体来合理设计配方。这些知识大多存在于药物传递领域之外的研究领域。因此，从药物传递的角度对这一主题进行全面综述是必要的。本文旨在确定影响多孔材料药物传递效果的加载过程和载体特性。此外，还阐明了多孔材料中药物释放的动力学，并概述了这些过程的数学建模的常用方法。
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