Department of Rehabilitation Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 286 Guangji Road, Suzhou, Jiangsu, 215000, China.
Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, Jiangsu, 215000, China.
BMC Neurol. 2023 May 25;23(1):205. doi: 10.1186/s12883-023-03231-5.
Participants with Parkinson's disease (PD) may experience difficulty during certain dual-task (DT) tests. Thus, it is necessary to keep the cognitive load within the limits of their ability.
To identify cognitive overload and its influence on the walking and auditory addition and subtraction (AAS, all values within the range of 0-20) DT performance of patients with PD.
A cross-sectional observational study with convenience sampling.
Outpatient clinic of the Department of Neurology.
Sixteen patients with PD and 15 sex- and age- matched people elderly healthy controls (HCs).
Verbal calculation responses and gait parameters were collected from the two groups in the 2-min single arithmetic task (2-min SAT), 2-min single walking task (2-min SWT), and 2-min walking-arithmetic dual task (2-min WADT).
The group differences in the lower-limb gait parameters increased in the 2-min WADT (P < 0.01), and those in the arm, trunk, and waist parameters did not change (P > 0.05). In the 2-min SAT, the calculation speed of the PD group was significantly lower than that of the HC group (P < 0.01). In the 2-min WADT, both groups made more errors (P < 0.05), especially the PD group (P = 0.00). PD group miscalculations occurred in the first half of the 2-min SAT but were uniformly distributed in the 2-min WADT. The HC group and PD group had subtraction self-correction rates of 31.25% and 10.25%, respectively. The PD group tended to make subtraction errors when the value of the first operand was 20 or 13.46 ± 2.60 and when the value of the second and third operands were 7.75 ± 2.51 (P = 0.3657) and 8.50 ± 4.04 (P = 0.170), respectively.
Cognitive overload was observed in patients with PD. This was mainly reflected in the failure of gait control and accurate calculation, indicated by gait parameters of the lower limbs and accuracy of calculation. To impose a constant cognitive load, the amount added or subtracted, especially in subtraction with borrowing, should not be mixed during a sequential arithmetic problem in the DT, and equations with the value of the first operand equal to 20 or approximately 13, the value of the second operand approximately 7, or the value of the third operand of approximately 9 should be excluded in the AAS DT.
Clinical trial registration number: ChiCTR1800020158.
帕金森病（PD）患者在进行某些双重任务（DT）测试时可能会遇到困难。因此，有必要将认知负荷控制在他们的能力范围内。
确定认知过载及其对 PD 患者行走和听觉加减法（AAS，所有值在 0-20 范围内）DT 表现的影响。
一项具有便利抽样的横断面观察性研究。
神经病学系门诊。
16 名 PD 患者和 15 名性别和年龄匹配的老年健康对照组（HCs）。
在 2 分钟的单项算术任务（2 分钟 SAT）、2 分钟单项步行任务（2 分钟 SWT）和 2 分钟步行-算术双重任务（2 分钟 WADT）中，收集两组的言语计算反应和步态参数。
在 2 分钟 WADT 中，下肢步态参数的组间差异增加（P<0.01），而手臂、躯干和腰部参数没有变化（P>0.05）。在 2 分钟 SAT 中，PD 组的计算速度明显低于 HC 组（P<0.01）。在 2 分钟 WADT 中，两组都犯了更多的错误（P<0.05），尤其是 PD 组（P=0.00）。PD 组在 2 分钟 SAT 的前半部分出现计算错误，但在 2 分钟 WADT 中均匀分布。HC 组和 PD 组的减法自我纠正率分别为 31.25%和 10.25%。PD 组在第一个操作数为 20 或 13.46±2.60 时，以及第二个和第三个操作数分别为 7.75±2.51（P=0.3657）和 8.50±4.04（P=0.170）时，倾向于出现减法错误。
PD 患者存在认知过载。这主要反映在步态控制和准确计算的失败上，表现为下肢的步态参数和计算的准确性。为了施加恒定的认知负荷，在 DT 中的顺序算术问题中，添加或减去的量，特别是带借位的减法，不应该混合，在 AAS DT 中，应该排除第一个操作数等于 20 或约 13、第二个操作数约为 7、或第三个操作数约为 9 的方程。
临床试验注册号：ChiCTR1800020158。
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