CDK16 在人类癌症中的作用、分子相互作用和治疗价值。
The roles, molecular interactions, and therapeutic value of CDK16 in human cancers.
机构信息
Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Graduate Department, Bengbu Medical College, Bengbu, Anhui, China.
出版信息
Biomed Pharmacother. 2023 Aug;164:114929. doi: 10.1016/j.biopha.2023.114929. Epub 2023 May 24.
Cyclin-dependent kinase 16 (CDK16) is an orphan "cyclin-dependent kinase" (CDK) involved in the cell cycle, vesicle trafficking, spindle orientation, skeletal myogenesis, neurite outgrowth, secretory cargo transport, spermatogenesis, glucose transportation, cell apoptosis, cell growth and proliferation, metastasis, and autophagy. Human CDK16 is located on chromosome Xp11.3 and is related to X-linked congenital diseases. CDK16 is commonly expressed in mammalian tissues and may act as an oncoprotein. It is a PCTAIRE kinase in which Cyclin Y or its homologue, Cyclin Y-like 1, regulates activity by binding to the N- and C- terminal regions of CDK16. CDK16 plays a vital role in various cancers, including lung cancer, prostate cancer, breast cancer, malignant melanoma, and hepatocellular carcinoma. CDK16 is a promising biomarker for cancer diagnosis and prognosis. In this review, we summarized and discussed the roles and mechanisms of CDK16 in human cancers.
周期蛋白依赖性激酶 16（CDK16）是一种孤儿“周期蛋白依赖性激酶”（CDK），参与细胞周期、囊泡运输、纺锤体定向、骨骼肌发生、神经突生长、分泌货物运输、精子发生、葡萄糖转运、细胞凋亡、细胞生长和增殖、转移和自噬。人类 CDK16 位于 Xp11.3 染色体上，与 X 连锁先天性疾病有关。CDK16 在哺乳动物组织中普遍表达，可能作为一种癌蛋白发挥作用。它是一种 PCTAIRE 激酶，其中 Cyclin Y 或其同源物 Cyclin Y-like 1 通过与 CDK16 的 N-和 C-末端区域结合来调节其活性。CDK16 在各种癌症中发挥着重要作用，包括肺癌、前列腺癌、乳腺癌、恶性黑色素瘤和肝细胞癌。CDK16 是癌症诊断和预后的有前途的生物标志物。在这篇综述中，我们总结和讨论了 CDK16 在人类癌症中的作用和机制。
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