Department of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, United States.
Department of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY, United States.
Semin Cancer Biol. 2023 Aug;93:123-128. doi: 10.1016/j.semcancer.2023.05.008. Epub 2023 May 24.
Small cell lung cancer (SCLC) is a recalcitrant cancer with an urgent need for novel therapeutics, preclinical models, and elucidation of the molecular pathways responsible for its rapid resistance. Recently, there have been many significant advancements in our knowledge of SCLC that led to the development of novel treatments. This review will go over the recent attempts to provide new molecular subcategorization of SCLC, recent breakthroughs in various systemic treatments including immunotherapy, targeted therapy, cellular therapy, as well as advancements in radiation therapy.
小细胞肺癌（SCLC）是一种难治性癌症，迫切需要新的治疗方法、临床前模型和阐明其快速耐药的分子途径。最近，我们对 SCLC 的认识有了许多重大进展，从而开发出了新的治疗方法。这篇综述将回顾最近尝试对 SCLC 进行新的分子分类，以及各种系统治疗（包括免疫疗法、靶向治疗、细胞疗法）的最新突破，以及放射治疗的进展。
