Macharia John M, Ngure Veronica, Emődy Barnabás, Király Bence, Káposztás Zsolt, Rozmann Nóra, Erdélyi Attila, Raposa Bence
Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pẻcs, 7624 Pecs, Hungary.
School of Science and Applied Technology, Laikipia University, Nyahururu P.O. Box 1100-20300, Kenya.
Pharmaceutics. 2023 May 22;15(5):1558. doi: 10.3390/pharmaceutics15051558.
species are widespread and diverse in African ecosystems, and this commonly correlates to their habitual use as reservoirs of herbal medicine. The side effects associated with chemotherapy and the development of antimicrobial resistance to empirically used antimicrobial drugs are substantial, paving the way for novel phytotherapeutic approaches. This comprehensive study aimed to evaluate and present as a compelling alternative with potential benefits in colorectal cancer (CRC) treatment. Important databases were systematically searched for relevant literature, and out of a large collection of 6421 titles and abstracts, only 68 full-text articles met the inclusion criteria. possesses an abundant presence of bioactive phytoconstituents in the leaves and roots, including anthraquinones, naphthoquinones, phenols, alkaloids, saponins, tannins, and flavonoids, among others. These metabolites have proven diverse efficacy in inhibiting cancer growth. The presence of innumerable biomolecules in signifies the beneficial effects of incorporating the plant as a potential anti-CRC agent. Nonetheless, we recommend further research to determine the optimal concentrations necessary to elicit beneficial effects in the management of CRC. Furthermore, they should be investigated as potential raw ingredients for making conventional medications.
该物种在非洲生态系统中分布广泛且种类多样,这通常与其作为草药储备的习惯性用途相关。与化疗相关的副作用以及对经验性使用的抗菌药物产生的抗药性问题严重,为新型植物治疗方法铺平了道路。这项全面的研究旨在评估并提出一种在结直肠癌(CRC)治疗中具有潜在益处的引人注目的替代方案。系统地检索了重要数据库以查找相关文献,在6421篇标题和摘要的大量收集中,只有68篇全文文章符合纳入标准。该植物的叶和根中含有丰富的生物活性植物成分,包括蒽醌、萘醌、酚类、生物碱、皂苷、单宁和黄酮类等。这些代谢产物已被证明在抑制癌症生长方面具有多种功效。该植物中存在无数生物分子,这表明将其作为潜在的抗CRC药物具有有益效果。尽管如此,我们建议进一步研究以确定在CRC管理中产生有益效果所需的最佳浓度。此外,它们应作为制造传统药物的潜在原料进行研究。