Wnt/β-连环蛋白信号通路在结直肠癌发生发展中的作用
Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer.
作者信息
He Kuang, Gan Wen-Juan
机构信息
Department of Pathology, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, Jiangsu, People's Republic of China.
出版信息
Cancer Manag Res. 2023 May 23;15:435-448. doi: 10.2147/CMAR.S411168. eCollection 2023.
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.
Wnt/β-连环蛋白信号通路是一条生长控制通路，参与多种生物学过程以及癌症的发生和发展。结直肠癌（CRC）是世界上最常见的恶性肿瘤之一。几乎在所有的结直肠癌中都观察到Wnt信号的过度激活，并且在癌症相关过程中发挥关键作用，如癌症干细胞（CSC）增殖、血管生成、上皮-间质转化（EMT）、化疗耐药和转移。本综述将讨论Wnt/β-连环蛋白信号通路如何参与结直肠癌的致癌作用和进展以及相关的治疗方法。
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