University of Oulu, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, P.O. Box 3000, 90014, Oulu, Finland.
Redox Biol. 2023 Jul;63:102753. doi: 10.1016/j.redox.2023.102753. Epub 2023 May 27.
Vitamin C is unbeatable - at least when it comes to sales. Of all the vitamin preparations, those containing vitamin C sell best. This is surprising because vitamin C deficiency is extremely rare. Nevertheless, there is still controversy about whether the additional intake of vitamin C supplements is essential for our health. In this context, the possible additional benefit is in most cases merely reduced to the known effect as an antioxidant. However, new findings in recent years on the mechanisms of oxygen-sensing and epigenetic control underpin the multifaceted role of vitamin C in a biological context and have therefore renewed interest in it. In the present article, therefore, known facts are linked to these new key data. In addition, available clinical data on vitamin C use of cancer therapy are summarized.
维生素 C 无可匹敌——至少在销售方面是这样。在所有的维生素制剂中，含维生素 C 的制剂卖得最好。这很令人惊讶，因为维生素 C 缺乏极其罕见。尽管如此，关于额外摄入维生素 C 补充剂是否对我们的健康至关重要，仍存在争议。在这种情况下，额外的益处大多数情况下仅仅被简化为作为抗氧化剂的已知作用。然而，近年来关于氧感应和表观遗传控制机制的新发现，为维生素 C 在生物学背景下的多方面作用提供了依据，因此重新引起了人们的兴趣。因此，本文将已知事实与这些新的关键数据联系起来。此外，还总结了有关癌症治疗中维生素 C 使用的现有临床数据。
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