Instituto de Investigación en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas, Córdoba, Argentina.
Department of Paediatric Neurology and Developmental Medicine, Hauner Children's Hospital, Ludwig Maximilian University of Munich (LMU), Munich, Germany.
Sci Rep. 2023 Jun 2;13(1):8947. doi: 10.1038/s41598-023-34634-6.
To analyze growth patterns of children with CP between countries; to examine differences in growth; and to assess the fit of growth charts. Cross-sectional study in children with CP from 2 to 19 years old, 399 from Argentina and 400 from Germany. Growth measures were converted into z-scores and compared to WHO reference and US CP growth charts. Generalized Linear Model was used to analyze the growth expressed as mean z-scores. 799 children. Mean age 9 years (± 4). Compared to the WHO reference, the decrease in Height z-scores (HAZ) with age in Argentina (- 0.144/year) was double that in Germany (- 0.073/year). For children in GMFCS IV-V, BMI z-scores (BMIZ) decreased with age (- 0.102/year). Using the US CP charts, both countries showed decreasing HAZ with age, in Argentina (- 0.066/year) and in Germany (- 0.032/year). BMIZ increased more among children with feeding tubes (0.062/year), similar in both countries. Argentinian children with oral feeding decrease their Weight z-score (WAZ) by - 0.553 compared to their peers. With WHO charts BMIZ presented an excellent fit for GMFCS I-III. HAZ presents a poor fit to growth references. BMIZ and WAZ presented a good fit to US CP Charts. Growth differences due to ethnicity also act in children with CP, and are related to motor impairment, age and feeding modality, possibly reflecting differences in environment or health care.
分析不同国家脑瘫儿童的生长模式;研究生长差异;评估生长图表的适配性。在年龄为 2 至 19 岁的脑瘫儿童中进行横断面研究,其中 399 名来自阿根廷,400 名来自德国。将生长指标转换为 z 分数,并与世界卫生组织(WHO)参考值和美国脑瘫儿童生长图表进行比较。使用广义线性模型分析以平均 z 分数表示的生长情况。共纳入 799 名儿童。平均年龄 9 岁(±4 岁)。与 WHO 参考值相比,阿根廷儿童身高 z 分数(HAZ)随年龄的下降速度(-0.144/年)是德国的两倍(-0.073/年)。对于 GMFCS IV-V 级别的儿童,BMI z 分数(BMIZ)随年龄的增加而降低(-0.102/年)。使用美国脑瘫儿童生长图表,两国儿童的 HAZ 均随年龄的增加而降低,阿根廷(-0.066/年)和德国(-0.032/年)。在有喂养管的儿童中,BMIZ 增加更多(0.062/年),两国情况相似。有口喂养的阿根廷儿童的 WAZ 比同龄人下降了-0.553。使用 WHO 图表,BMIZ 与 GMFCS I-III 具有极佳的适配性。HAZ 与生长参考值拟合不良。BMIZ 和 WAZ 与美国脑瘫儿童生长图表具有良好的适配性。由于种族差异,脑瘫儿童的生长也存在差异,并且与运动障碍、年龄和喂养方式有关,这可能反映了环境或医疗保健方面的差异。