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METS-VF 能否为肾结石的形成提供线索?

Could METS-VF provide a clue as to the formation of kidney stones?

机构信息

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Institute of Urology, Anhui Medical University, Hefei, China.

出版信息

Front Endocrinol (Lausanne). 2023 May 22;14:1166922. doi: 10.3389/fendo.2023.1166922. eCollection 2023.

Abstract

OBJECTIVE

The lifetime occurrence rate of kidney stones is 14%, making it one of the most prevalent urological conditions. Other contributing elements, such as obesity, diabetes, diet, and heredity, are also taken into account. Our research sought to explore the potential link between high visceral fat scores (METS-VF) and the occurrence of kidney stones, as a means of understanding how to prevent them.

METHODS

This research utilized data from the National Health and Nutrition Examination Survey (NHANES), mirroring the demographics of the United States. We carried out an in-depth analysis of the connection between METS-VF and kidney stones, based on data from 29,246 participants in the National Health and Nutrition Examination Survey spanning 2007 to 2018, involving logistic regression, segmentation, and dose-response curve analysis.

RESULTS

Our study of 29,246 potential participants found that METS-VF was positively associated with the prevalence and progression of kidney stones. After subgroup analysis by gender, race, blood pressure, and blood glucose, our results showed that the ORs for METS-VF and kidney stones were (1.49, 1.44) in males and females, respectively; while in Mexicans, whites, blacks, and In other populations, the OR values were (1.33, 1.43, 1.54, 1.86); in hypertensive and normal populations, the OR values were (1.23, 1.48); in diabetic patients and normoglycemic patients were (1.36,1.43). This proves that it works for all groups of people.

SUMMARY

Our studies demonstrate a strong connection between METS-FV and the emergence of kidney stones. It would be beneficial to investigate METS-VF as a marker for kidney stone development and progression in light of these findings.

摘要

目的

肾结石的终身发生率为 14%,是最常见的泌尿科疾病之一。肥胖、糖尿病、饮食和遗传等其他因素也被考虑在内。我们的研究旨在探讨高内脏脂肪评分(METS-VF)与肾结石发生之间的潜在联系,以期了解如何预防肾结石。

方法

本研究利用了全国健康和营养检查调查(NHANES)的数据,反映了美国的人口统计学特征。我们对 METS-VF 与肾结石之间的关系进行了深入分析,基于 2007 年至 2018 年期间 29246 名参与全国健康和营养检查调查的参与者的数据,采用逻辑回归、分割和剂量反应曲线分析。

结果

我们对 29246 名潜在参与者的研究发现,METS-VF 与肾结石的患病率和进展呈正相关。在按性别、种族、血压和血糖进行亚组分析后,我们的结果表明,METS-VF 和肾结石的 OR 值分别为男性和女性的(1.49,1.44);而在墨西哥人、白种人、黑人和其他人群中,OR 值分别为(1.33,1.43,1.54,1.86);在高血压和正常人群中,OR 值分别为(1.23,1.48);在糖尿病患者和血糖正常患者中,OR 值分别为(1.36,1.43)。这证明它对所有人群都有效。

总结

我们的研究表明,METS-FV 与肾结石的发生之间存在很强的联系。鉴于这些发现,将 METS-VF 作为肾结石发生和进展的标志物进行研究将是有益的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faee/10240079/bf021ae5781f/fendo-14-1166922-g001.jpg

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