Holmes R A, Wilson R C, McCall J W
Am J Vet Res. 1986 Jun;47(6):1338-40.
The pharmacokinetic values of thiacetarsamide (2.2 mg/kg) were determined in 6 healthy dogs after IV injection. A semilogarithmic plot of serum concentration vs time indicated that the 2-compartment open model best described thiacetarsamide disposition. A least-squares log linear regression microcomputer program was used to calculate the pharmacokinetic values. The mean elimination-phase half-life and clearance rate were 43 minutes and 200 ml/kg/min, respectively. Wide ranges in values were seen for the half-life (20.5 to 83.4 minutes) and the clearance rate (80.0 to 350.0 ml/kg/min). Before thiacetarsamide was given to the dogs, indocyanine green (ICG), an anionic dye that is eliminated almost entirely by hepatobiliary excretion, was administered IV at a dosage of 0.5 mg/kg of body weight. The half-life of ICG was 7.4 minutes, and the clearance rate was 8.43 ml/kg/min. There was a significant (P less than 0.01) correlation between the half-lives of thiacetarsamide and ICG, but not between the clearance rates. The variations in ICG half-lives and clearance rates were less than those seen for thiacetarsamide.
静脉注射后，测定了6只健康犬体内硫胂酰胺（2.2毫克/千克）的药代动力学值。血清浓度与时间的半对数图表明，二室开放模型最能描述硫胂酰胺的处置情况。使用最小二乘对数线性回归微机程序计算药代动力学值。平均消除相半衰期和清除率分别为43分钟和200毫升/千克/分钟。半衰期（20.5至83.4分钟）和清除率（80.0至350.0毫升/千克/分钟）的值范围较宽。在给犬使用硫胂酰胺之前，静脉注射了吲哚菁绿（ICG），这是一种几乎完全通过肝胆排泄消除的阴离子染料，剂量为0.5毫克/千克体重。ICG的半衰期为7.4分钟，清除率为8.43毫升/千克/分钟。硫胂酰胺和ICG的半衰期之间存在显著（P小于0.01）相关性，但清除率之间不存在相关性。ICG半衰期和清除率的变化小于硫胂酰胺的变化。
