[基因rs2587552多态性对儿童肥胖干预效果的影响：一项前瞻性平行组对照试验]
[Influence of rs2587552 polymorphism of gene on the effect of a childhood obesity intervention: A prospective, parallel-group controlled trial].
作者信息
Chen J, Xiao W C, Shan R, Song J Y, Liu Z
机构信息
Department of Maternal and Child Health, Peking University School of Public Health, Beijing 100191, China.
Institute of Child and Adolescent Health, Peking University School of Public Health, Beijing 100191, China.
出版信息
Beijing Da Xue Xue Bao Yi Xue Ban. 2023 Jun 18;55(3):436-441. doi: 10.19723/j.issn.1671-167X.2023.03.008.
OBJECTIVE
To explore the association between rs2587552 polymorphism (has a strong lin-kage disequilibrium with rs1800497 which had been found in many studies to be related to obesity, =0.85) of gene and the effect of a childhood obesity intervention in Chinese population, and provide a scientific basis for future personalized childhood obesity intervention based on genetic background.
METHODS
From a multi-center cluster randomized controlled trial studying the effect of a childhood obesity intervention, we enrolled 382 children from 8 primary schools (192 and 190 children from intervention and control groups, respectively) in Beijing as study subjects. Saliva was collected and DNA was extracted to detect the rs2587552 polymorphism of gene, and the interactions between the gene and study arms on childhood obesity indicators [including body weight, body mass index (BMI), BMI Z-score, waist circumference, hip circumference, waist-to-hip ratio, waist-to-height ratio, and body fat percentage] were analyzed.
RESULTS
No association was found between rs2587552 polymorphism and the changes in hip circumference or body fat percentage in the intervention group (>0.05). However, in the control group, children carrying the A allele at rs2587552 locus showed a greater increase in hip circumference and body fat percentage compared with those not carrying A allele ( < 0.001). There were interactions between rs2587552 polymorphism of gene and study arms on the changes in hip circumference and body fat percentage (=0.007 and 0.015, respectively). Compared with the control group, children in the intervention group carrying the A allele at rs2587552 locus showed decrease in hip circumference by (-1.30 cm, 95%: -2.25 to -0.35, =0.007) and decrease in body fat percentage by (-1.34%, 95%: -2.42 to -0.27, =0.015) compared with those not carrying A allele. The results were consistent between the dominant model and the additive model (hip circumfe-rence: -0.66 cm, 95%: -1.28 to -0.03, =0.041; body fat percentage: -0.69%, 95%: -1.40 to 0.02, =0.056). No interaction was found between rs2587552 polymorphism and study arms on the changes in other childhood obesity-related indicators (>0.05).
CONCLUSION
Children carrying the A allele at rs2587552 polymorphism of gene are more sensitive to intervention and showed more improvement in hip circumference and body fat percentage after the intervention, suggesting that future personalized childhood obesity lifestyle intervention can be carried out based on the rs2587552 polymorphism of gene.
目的
探讨基因rs2587552多态性（与rs1800497存在强连锁不平衡，许多研究发现rs1800497与肥胖相关，r = 0.85）与中国人群儿童肥胖干预效果之间的关联，为未来基于遗传背景的个性化儿童肥胖干预提供科学依据。
方法
从一项研究儿童肥胖干预效果的多中心整群随机对照试验中，选取北京8所小学的382名儿童（干预组192名，对照组190名）作为研究对象。采集唾液并提取DNA，检测基因的rs2587552多态性，分析该基因与研究分组在儿童肥胖指标[包括体重、体重指数（BMI）、BMI Z评分、腰围、臀围、腰臀比、腰高比和体脂百分比]上的相互作用。
结果
干预组中，rs2587552多态性与臀围或体脂百分比的变化之间未发现关联（P>0.05）。然而，在对照组中，rs2587552位点携带A等位基因的儿童与未携带A等位基因的儿童相比，臀围和体脂百分比的增加幅度更大（P<0.001）。基因的rs2587552多态性与研究分组在臀围和体脂百分比变化上存在相互作用（P分别为0.007和0.015）。与对照组相比，干预组中rs2587552位点携带A等位基因的儿童与未携带A等位基因的儿童相比，臀围减少了（-1.30 cm，95%CI：-2.25至-0.35，P = 0.007），体脂百分比减少了（-1.34%，95%CI：-2.42至-0.27，P = 0.015）。显性模型和加性模型的结果一致（臀围：-0.66 cm，95%CI：-1.28至-0.03，P = 0.041；体脂百分比：-0.69%，95%CI：-1.40至0.02，P = 0.056）。rs2587552多态性与研究分组在其他儿童肥胖相关指标变化上未发现相互作用（P>0.05）。
结论
基因rs2587552多态性携带A等位基因的儿童对干预更敏感，干预后臀围和体脂百分比改善更明显，提示未来可基于基因的rs2587552多态性进行个性化儿童肥胖生活方式干预。
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